Molecular strategies for the utilisation of human milk oligosaccharides by infant gut-associated bacteria.
Lactobacillus
Bifidobacteria
human milk oligosaccharides
infant gut microbiota
prebiotics
probiotics
Journal
FEMS microbiology reviews
ISSN: 1574-6976
Titre abrégé: FEMS Microbiol Rev
Pays: England
ID NLM: 8902526
Informations de publication
Date de publication:
01 11 2023
01 11 2023
Historique:
received:
21
04
2023
revised:
14
09
2023
accepted:
03
10
2023
medline:
7
11
2023
pubmed:
5
10
2023
entrez:
4
10
2023
Statut:
ppublish
Résumé
A number of bacterial species are found in high abundance in the faeces of healthy breast-fed infants, an occurrence that is understood to be, at least in part, due to the ability of these bacteria to metabolize human milk oligosaccharides (HMOs). HMOs are the third most abundant component of human milk after lactose and lipids, and represent complex sugars which possess unique structural diversity and are resistant to infant gastrointestinal digestion. Thus, these sugars reach the infant distal intestine intact, thereby serving as a fermentable substrate for specific intestinal microbes, including Firmicutes, Proteobacteria, and especially infant-associated Bifidobacterium spp. which help to shape the infant gut microbiome. Bacteria utilising HMOs are equipped with genes associated with their degradation and a number of carbohydrate-active enzymes known as glycoside hydrolase enzymes have been identified in the infant gut, which supports this hypothesis. The resulting degraded HMOs can also be used as growth substrates for other infant gut bacteria present in a microbe-microbe interaction known as 'cross-feeding'. This review describes the current knowledge on HMO metabolism by particular infant gut-associated bacteria, many of which are currently used as commercial probiotics, including the distinct strategies employed by individual species for HMO utilisation.
Identifiants
pubmed: 37793834
pii: 7289236
doi: 10.1093/femsre/fuad056
pmc: PMC10629584
pii:
doi:
Substances chimiques
Oligosaccharides
0
Sugars
0
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Science Foundation Ireland
Pays : Ireland
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of FEMS.
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