Syphilis and the host: multi-omic analysis of host cellular responses to
Treponema pallidum
disease symptoms
dissemination
proteomics
syphilis
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2023
2023
Historique:
received:
07
07
2023
accepted:
01
09
2023
medline:
5
10
2023
pubmed:
5
10
2023
entrez:
5
10
2023
Statut:
epublish
Résumé
Syphilis is a chronic, multi-stage infection caused by the extracellular bacterium To address this knowledge gap, we used quantitative proteomics and cytokine profiling to characterize endothelial responses to Proteomic analyses detected altered host pathways controlling extracellular matrix organization, necroptosis and cell death, and innate immune signaling. Cytokine analyses of endothelial cells exposed to This study provides insight into the molecular basis of syphilis disease symptoms and the enhanced susceptibility of individuals infected with syphilis to HIV co-infection. These investigations also enhance understanding of the host response to
Identifiants
pubmed: 37795301
doi: 10.3389/fmicb.2023.1254342
pmc: PMC10546344
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1254342Subventions
Organisme : NIAID NIH HHS
ID : R37 AI051334
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI144133
Pays : United States
Informations de copyright
Copyright © 2023 Waugh, Ranasinghe, Gomez, Houston, Lithgow, Eshghi, Fleetwood, Conway, Reynolds and Cameron.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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