Acupuncture as multi-targeted therapy for the multifactorial disease obesity: a complex neuro-endocrine-immune interplay.
acupuncture
appetite regulating hormones
chronic low-grade inflammation
gut microbiota dysbiosis
insulin resistance
leptin resistance
obesity
weight-loss
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
07
06
2023
accepted:
29
08
2023
medline:
1
11
2023
pubmed:
5
10
2023
entrez:
5
10
2023
Statut:
epublish
Résumé
The prevalence of obesity has reached pandemic dimensions. It is associated with multiple comorbidities and is becoming a clinical and public health threat. Obesity is a multifactorial disease with a complex pathophysiology and interplay of various systems. A strong interplay exists between the neuro-endocrine system, the immune system with systemic chronic low-grade inflammation, and microbiome dysbiosis that can lead to the development of obesity, which in turn can exacerbate each of these factors, hence creating a vicious cycle. The conventional treatment with lifestyle modifications such as diet, physical exercise, pharmacotherapy, and bariatric surgery does not always result in sufficient weight control thus paving the way for other strategies. As one such strategy, acupuncture is increasingly used worldwide to treat obesity. This narrative review outlines the evidence for this neuro-endocrine-immune interplay in the pathophysiology of obesity. Furthermore, the existing experimental and clinical evidence of acupuncture as a multi-targeted therapy for obesity is explained and future research perspectives are discussed.
Identifiants
pubmed: 37795371
doi: 10.3389/fendo.2023.1236370
pmc: PMC10545882
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1236370Informations de copyright
Copyright © 2023 Landgraaf, Bloem, Fumagalli, Benninga, de Lorijn and Nieuwdorp.
Déclaration de conflit d'intérêts
MF is the founder and main shareholder of Sinomedica, RGL is a minor shareholder of Sinomedica and receives a salary for this research work. Sinomedica is a group of 7 centers in Switzerland performing medical acupuncture. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be constructed as a potential conflict of interest.
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