'Chip'-ing away at morphogenesis - application of organ-on-chip technologies to study tissue morphogenesis.
Cell and developmental biology
Microphysiological systems
Organ-on-chip
Organoids
Tissue morphogenesis
Journal
Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457
Informations de publication
Date de publication:
01 10 2023
01 10 2023
Historique:
pmc-release:
05
10
2024
medline:
6
10
2023
pubmed:
5
10
2023
entrez:
5
10
2023
Statut:
ppublish
Résumé
Emergent cell behaviors that drive tissue morphogenesis are the integrated product of instructions from gene regulatory networks, mechanics and signals from the local tissue microenvironment. How these discrete inputs intersect to coordinate diverse morphogenic events is a critical area of interest. Organ-on-chip technology has revolutionized the ability to construct and manipulate miniaturized human tissues with organotypic three-dimensional architectures in vitro. Applications of organ-on-chip platforms have increasingly transitioned from proof-of-concept tissue engineering to discovery biology, furthering our understanding of molecular and mechanical mechanisms that operate across biological scales to orchestrate tissue morphogenesis. Here, we provide the biological framework to harness organ-on-chip systems to study tissue morphogenesis, and we highlight recent examples where organ-on-chips and associated microphysiological systems have enabled new mechanistic insight in diverse morphogenic settings. We further highlight the use of organ-on-chip platforms as emerging test beds for cell and developmental biology.
Identifiants
pubmed: 37795818
pii: 330773
doi: 10.1242/jcs.261130
pmc: PMC10565497
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R00 CA226366
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG072232
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM150987
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM151099
Pays : United States
Informations de copyright
© 2023. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing or financial interests.
Références
Cell Syst. 2019 Sep 25;9(3):221-227
pubmed: 31557453
Adv Healthc Mater. 2016 Jan 21;5(2):198-204
pubmed: 26610188
Development. 2016 Feb 1;143(3):427-36
pubmed: 26721501
Nature. 2008 Jun 5;453(7196):745-50
pubmed: 18463632
Dev Cell. 2015 Sep 28;34(6):719-26
pubmed: 26387457
Cell. 2009 Nov 25;139(5):891-906
pubmed: 19931152
Nat Methods. 2014 Aug;11(8):847-54
pubmed: 24973948
Curr Biol. 2013 Apr 22;23(8):703-9
pubmed: 23562267
Lab Chip. 2012 Dec 7;12(23):5000-6
pubmed: 23073300
Nat Cell Biol. 2021 Jul;23(7):745-757
pubmed: 34155382
Cell Stem Cell. 2017 Oct 5;21(4):472-488.e10
pubmed: 28965766
Nat Commun. 2021 Aug 26;12(1):5140
pubmed: 34446708
PLoS One. 2015 Jul 16;10(7):e0132580
pubmed: 26182056
Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8167-8172
pubmed: 30038020
Sci Adv. 2023 Jan 20;9(3):eadd5668
pubmed: 36662859
Nature. 2009 May 14;459(7244):262-5
pubmed: 19329995
Int Rev Cell Mol Biol. 2011;288:101-65
pubmed: 21482411
Nature. 2020 Sep;585(7825):426-432
pubmed: 32908310
Cold Spring Harb Perspect Biol. 2011 Aug 01;3(8):a005090
pubmed: 21807843
Science. 2019 Aug 16;365(6454):705-710
pubmed: 31416964
Nature. 2020 Aug;584(7822):535-546
pubmed: 32848221
iScience. 2019 May 31;15:391-406
pubmed: 31108394
APL Bioeng. 2018 Oct 11;2(4):040901
pubmed: 31069321
Curr Opin Biotechnol. 2018 Aug;52:42-48
pubmed: 29505976
Dev Cell. 2021 Jan 25;56(2):180-191
pubmed: 33453155
Nat Rev Mol Cell Biol. 2021 Apr;22(4):245-265
pubmed: 33483696
Science. 2019 Jun 07;364(6444):960-965
pubmed: 31171693
Nat Protoc. 2022 Mar;17(3):910-939
pubmed: 35110737
Integr Biol (Camb). 2016 Sep 12;8(9):918-28
pubmed: 27476872
Cell Stem Cell. 2021 Jan 7;28(1):79-95.e8
pubmed: 33098807
Cell. 2021 Jul 8;184(14):3702-3716.e30
pubmed: 34133940
Development. 2013 Oct;140(19):4041-50
pubmed: 24004946
Nature. 2023 Feb;614(7946):144-152
pubmed: 36509107
Science. 2002 May 10;296(5570):1046-9
pubmed: 12004111
Integr Biol (Camb). 2013 Sep;5(9):1130-40
pubmed: 23817533
Sci Rep. 2015 Jul 13;5:11458
pubmed: 26165921
Science. 2019 May 3;364(6439):458-464
pubmed: 31048486
Science. 2006 Oct 13;314(5797):298-300
pubmed: 17038622
Dev Cell. 2018 Apr 23;45(2):183-197.e5
pubmed: 29689194
Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):7968-73
pubmed: 24843171
Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):E2595-604
pubmed: 22923691
Nat Mater. 2021 Jan;20(1):22-29
pubmed: 32958879
Nat Commun. 2022 Sep 14;13(1):5400
pubmed: 36104355
Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2287-92
pubmed: 25633040
Nature. 2013 Sep 19;501(7467):373-9
pubmed: 23995685
Adv Funct Mater. 2022 Oct 21;32(43):
pubmed: 36569597
Elife. 2021 Oct 18;10:
pubmed: 34661524
Nature. 2021 Dec;600(7888):285-289
pubmed: 34789876
Cell. 2013 Jul 18;154(2):274-84
pubmed: 23870119
Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9230-5
pubmed: 26170292
Science. 2019 Jun 07;364(6444):956-959
pubmed: 31171692
Sci Rep. 2018 Feb 13;8(1):2871
pubmed: 29440725
Lab Chip. 2013 Aug 21;13(16):3246-52
pubmed: 23787488
Cell Syst. 2016 Nov 23;3(5):456-466.e4
pubmed: 27894999
Development. 2022 Jan 15;149(2):
pubmed: 35051272
Science. 2013 Oct 11;342(6155):212-8
pubmed: 23989955
Mol Biol Cell. 2019 Jul 22;30(16):1974-1984
pubmed: 31318321
Cell Stem Cell. 2021 Sep 2;28(9):1516-1532.e14
pubmed: 33915079
Nature. 2020 Jun;582(7811):253-258
pubmed: 32523119
Sci Rep. 2014 Dec 10;4:7402
pubmed: 25492588
Nature. 2019 Sep;573(7774):421-425
pubmed: 31511693
Semin Cell Dev Biol. 2017 Jul;67:101-102
pubmed: 28648529
Nat Commun. 2023 May 30;14(1):3128
pubmed: 37253730
Development. 2020 May 22;147(10):
pubmed: 32444428
Nature. 2017 Dec 14;552(7684):258-262
pubmed: 29160307
Nature. 2020 Dec;588(7836):130-134
pubmed: 33208950
Biochim Biophys Acta. 2009 May;1793(5):903-10
pubmed: 19167433
Nat Commun. 2020 Jul 6;11(1):3377
pubmed: 32632100
Dev Dyn. 2013 Jun;242(6):622-37
pubmed: 23483685
Nat Protoc. 2019 May;14(5):1425-1454
pubmed: 30953042
Biomaterials. 2022 Jan;280:121248
pubmed: 34794827
Nat Commun. 2020 Apr 6;11(1):1711
pubmed: 32249764
Mol Biol Cell. 2012 Mar;23(5):781-91
pubmed: 22238361
Nat Cell Biol. 2021 Jul;23(7):733-744
pubmed: 34155381
Development. 2017 Dec 1;144(23):4328-4335
pubmed: 29084801
Development. 2017 Dec 1;144(23):4249-4260
pubmed: 29183938
Proc Natl Acad Sci U S A. 2021 May 11;118(19):
pubmed: 33941687
Elife. 2020 Nov 03;9:
pubmed: 33141023
Science. 2022 Jan 07;375(6576):eaaw9021
pubmed: 34990240
Science. 2018 Jul 13;361(6398):156-162
pubmed: 29853554
Curr Biol. 2020 Sep 7;30(17):3414-3424.e3
pubmed: 32707057
Cell Stem Cell. 2020 Nov 5;27(5):798-812.e6
pubmed: 32931729
Cold Spring Harb Perspect Biol. 2012 Oct 01;4(10):
pubmed: 22798543
Lab Chip. 2020 Aug 7;20(15):2776-2787
pubmed: 32614340
Nat Methods. 2016 Apr 28;13(5):415-23
pubmed: 27123817
Lab Chip. 2020 Mar 17;20(6):1153-1166
pubmed: 32100769
Curr Biol. 2021 May 10;31(9):1903-1917.e6
pubmed: 33705716
Nature. 2019 May;569(7754):66-72
pubmed: 31019299
Dev Cell. 2018 Apr 9;45(1):67-82.e6
pubmed: 29634937
Dev Cell. 2023 Jan 23;58(2):110-120.e5
pubmed: 36693318
J Cell Biol. 2018 Oct 1;217(10):3368-3381
pubmed: 30061105
J Cell Biol. 2017 Mar 6;216(3):559-570
pubmed: 28174204
Semin Cell Dev Biol. 2017 Jun;66:81-93
pubmed: 28161556
Dev Cell. 2017 Sep 25;42(6):567-583
pubmed: 28950100
Cell Rep. 2018 Jun 19;23(12):3698
pubmed: 29925009
Nature. 2020 Sep;585(7826):574-578
pubmed: 32939089
Science. 2010 Jun 25;328(5986):1662-8
pubmed: 20576885
Nat Commun. 2021 Jun 7;12(1):3402
pubmed: 34099677
Semin Cell Dev Biol. 2014 Jul;31:124-31
pubmed: 24747369
Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15817-22
pubmed: 23019366