In vitro susceptibility to miltefosine of amphotericin B-resistant Leishmania (Mundinia) martiniquensis.
Amphotericin B
Drug resistance
Leishmania martiniquensis
Miltefosine
Relapse
Thailand
Journal
Parasitology research
ISSN: 1432-1955
Titre abrégé: Parasitol Res
Pays: Germany
ID NLM: 8703571
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
25
04
2023
accepted:
26
09
2023
medline:
27
11
2023
pubmed:
5
10
2023
entrez:
5
10
2023
Statut:
ppublish
Résumé
Leishmania (Mundinia) martiniquensis is a newly described species that causes human visceral, disseminated, and mucocutaneous leishmaniases. Amphotericin B deoxycholate (AmpB) is the first-line drug for the treatment of leishmaniasis in Thailand; however, several relapse cases of leishmaniasis caused by L. martiniquensis have been documented. In this study, in vitro susceptibility to AmpB and miltefosine (MIL) of wild-type (before treatment, LSCM1) and two AmpB-resistant L. martiniquensis strains (an in vitro-induced AmpB-resistant strain, AmpBRP2i, and a relapse strain, LSCM1-6) were determined. Results reveal that the IC
Identifiants
pubmed: 37796293
doi: 10.1007/s00436-023-07992-3
pii: 10.1007/s00436-023-07992-3
doi:
Substances chimiques
Amphotericin B
7XU7A7DROE
miltefosine
53EY29W7EC
Phosphorylcholine
107-73-3
Antiprotozoal Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3027-3035Subventions
Organisme : Faculty of Medicine, Chiang Mai University
ID : grant number 128-2562
Organisme : Thailand Graduate Institute of Science and Technology (TGIST) and NSTDA
ID : grant number TG-22-10-60-001D
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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