Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas.
Islr
Meflin
cancer-associated fibroblast
chronic pancreatitis
fibroblast
fibrosis
pancreas
pancreatic ductal adenocarcinoma
pancreatic stellate cell
Journal
The Journal of pathology
ISSN: 1096-9896
Titre abrégé: J Pathol
Pays: England
ID NLM: 0204634
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
revised:
18
07
2023
received:
24
01
2023
accepted:
25
08
2023
medline:
7
12
2023
pubmed:
5
10
2023
entrez:
5
10
2023
Statut:
ppublish
Résumé
Pancreatic stellate cells (PSCs) are stromal cells in the pancreas that play an important role in pancreatic pathology. In chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), PSCs are known to get activated to form myofibroblasts or cancer-associated fibroblasts (CAFs) that promote stromal fibroinflammatory reactions. However, previous studies on PSCs were mainly based on the findings obtained using ex vivo expanded PSCs, with few studies that addressed the significance of in situ tissue-resident PSCs using animal models. Their contributions to fibrotic reactions in CP and PDAC are also lesser-known. These limitations in our understanding of PSC biology have been attributed to the lack of specific molecular markers of PSCs. Herein, we established Meflin (Islr), a glycosylphosphatidylinositol-anchored membrane protein, as a PSC-specific marker in both mouse and human by using human pancreatic tissue samples and Meflin reporter mice. Meflin-positive (Meflin
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
61-75Subventions
Organisme : Daiko Foundation
Organisme : Japan Agency for Medical Research and Development
ID : 23ck0106706h0003
Organisme : Japan Agency for Medical Research and Development
ID : 23ck0106779h0002
Organisme : Japan Agency for Medical Research and Development
ID : 23gm1210009s0105
Organisme : Japan Society for the Promotion of Science
ID : 20H03467
Organisme : Japan Society for the Promotion of Science
ID : 22H02848
Organisme : Japan Society for the Promotion of Science
ID : 22K18390
Organisme : Naito Foundation
Organisme : Princess Takamatsu Cancer Research Fund
Organisme : Takeda Science Foundation
Organisme : Toyoaki Foundation
Organisme : Takamatsunomiya Cancer Foundation
Informations de copyright
© 2023 The Pathological Society of Great Britain and Ireland.
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