Benign recurrent lymphocytic meningitis (Mollaret's meningitis) in Denmark: a nationwide cohort study.

aciclovir aseptic meningitis herpes simplex virus type 2 viral meningitis

Journal

European journal of neurology
ISSN: 1468-1331
Titre abrégé: Eur J Neurol
Pays: England
ID NLM: 9506311

Informations de publication

Date de publication:
Jan 2024
Historique:
revised: 15 09 2023
received: 08 08 2023
accepted: 18 09 2023
pubmed: 5 10 2023
medline: 5 10 2023
entrez: 5 10 2023
Statut: ppublish

Résumé

Data on clinical features and outcomes of benign recurrent lymphocytic meningitis (BRLM) are limited. This was a nationwide population-based cohort study of all adults hospitalized for BRLM associated with herpes simplex virus type 2 (HSV-2) at the departments of infectious diseases in Denmark from 2015 to 2020. Patients with single-episode HSV-2 meningitis were included for comparison. Forty-seven patients with BRLM (mean annual incidence 1.2/1,000,000 adults) and 118 with single-episode HSV-2 meningitis were included. The progression risk from HSV-2 meningitis to BRLM was 22% (95% confidence interval [CI] 15%-30%). The proportion of patients with the triad of headache, neck stiffness and photophobia/hyperacusis was similar between BRLM and single-episode HSV-2 meningitis (16/43 [37%] vs. 46/103 [45%]; p = 0.41), whilst the median cerebrospinal fluid leukocyte count was lower in BRLM (221 cells vs. 398 cells; p = 0.02). Unfavourable functional outcomes (Glasgow Outcome Scale score of 1-4) were less frequent in BRLM at all post-discharge follow-up visits. During the study period, 10 (21%) patients with BRLM were hospitalized for an additional recurrence (annual rate 6%, 95% CI 3%-12%). The hazard ratio for an additional recurrence was 3.93 (95% CI 1.02-15.3) for patients with three or more previous episodes of meningitis. Clinical features of BRLM were similar to those of single-episode HSV-2 meningitis, whilst post-discharge outcomes were more favourable. Patients with three or more previous episodes of meningitis had higher risk of an additional recurrence.

Sections du résumé

BACKGROUND AND PURPOSE OBJECTIVE
Data on clinical features and outcomes of benign recurrent lymphocytic meningitis (BRLM) are limited.
METHODS METHODS
This was a nationwide population-based cohort study of all adults hospitalized for BRLM associated with herpes simplex virus type 2 (HSV-2) at the departments of infectious diseases in Denmark from 2015 to 2020. Patients with single-episode HSV-2 meningitis were included for comparison.
RESULTS RESULTS
Forty-seven patients with BRLM (mean annual incidence 1.2/1,000,000 adults) and 118 with single-episode HSV-2 meningitis were included. The progression risk from HSV-2 meningitis to BRLM was 22% (95% confidence interval [CI] 15%-30%). The proportion of patients with the triad of headache, neck stiffness and photophobia/hyperacusis was similar between BRLM and single-episode HSV-2 meningitis (16/43 [37%] vs. 46/103 [45%]; p = 0.41), whilst the median cerebrospinal fluid leukocyte count was lower in BRLM (221 cells vs. 398 cells; p = 0.02). Unfavourable functional outcomes (Glasgow Outcome Scale score of 1-4) were less frequent in BRLM at all post-discharge follow-up visits. During the study period, 10 (21%) patients with BRLM were hospitalized for an additional recurrence (annual rate 6%, 95% CI 3%-12%). The hazard ratio for an additional recurrence was 3.93 (95% CI 1.02-15.3) for patients with three or more previous episodes of meningitis.
CONCLUSIONS CONCLUSIONS
Clinical features of BRLM were similar to those of single-episode HSV-2 meningitis, whilst post-discharge outcomes were more favourable. Patients with three or more previous episodes of meningitis had higher risk of an additional recurrence.

Identifiants

pubmed: 37797296
doi: 10.1111/ene.16081
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e16081

Subventions

Organisme : A & J C Tvergaards Fond
Organisme : Helen Rudes Fond
ID : 60988
Organisme : Helsefonden
ID : 21-B-0437
Organisme : Minister Erna Hamiltons Legat for Videnskab og Kunst
ID : 24-2022
Organisme : Nordsjaellands Hospital

Informations de copyright

© 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.

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Auteurs

Pelle Trier Petersen (PT)

Department of Pulmonary and Infectious Diseases, Nordsjaellands Hospital, Hillerød, Denmark.
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Jacob Bodilsen (J)

Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark.
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Micha Phill Grønholm Jepsen (MPG)

Department of Pulmonary and Infectious Diseases, Nordsjaellands Hospital, Hillerød, Denmark.

Birgitte Rønde Hansen (BR)

Department of Infectious Diseases, Hvidovre Hospital, Hvidovre, Denmark.

Merete Storgaard (M)

Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.

Lykke Larsen (L)

Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.

Jannik Helweg-Larsen (J)

Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.

Lothar Wiese (L)

Department of Medicine, Zealand University Hospital, Roskilde, Denmark.

Hans Rudolf Lüttichau (HR)

Department of Infectious Diseases, Herlev Hospital, Herlev, Denmark.

Christian Østergaard Andersen (CØ)

Department of Clinical Microbiology, Hvidovre Hospital, Hvidovre, Denmark.

Trine Hyrup Mogensen (TH)

Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
Department of Biomedicine, Aarhus University Hospital, Aarhus, Denmark.

Henrik Nielsen (H)

Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark.
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Christian Thomas Brandt (CT)

Department of Medicine, Zealand University Hospital, Roskilde, Denmark.

Classifications MeSH