Integrated multi-omics analysis of brain aging in female nonhuman primates reveals altered signaling pathways relevant to age-related disorders.

Humans Animals Female Multiomics Aging / psychology Signal Transduction / genetics Prefrontal Cortex / metabolism Cognitive Dysfunction / genetics
Brain prefrontal cortex Integrated omics Nonhuman primate Normal aging

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 20 04 2023
revised: 25 08 2023
accepted: 27 08 2023
medline: 6 11 2023
pubmed: 6 10 2023
entrez: 5 10 2023
Statut: ppublish

Résumé

The prefrontal cortex (PFC) has been implicated as a key brain region responsible for age-related cognitive decline. Little is known about aging-related molecular changes in PFC that may mediate these effects. To date, no studies have used untargeted discovery methods with integrated analyses to determine PFC molecular changes in healthy female primates. We quantified PFC changes associated with healthy aging in female baboons by integrating multiple omics data types (transcriptomics, proteomics, metabolomics) from samples across the adult age span. Our integrated omics approach using unbiased weighted gene co-expression network analysis to integrate data and treat age as a continuous variable, revealed highly interconnected known and novel pathways associated with PFC aging. We found Gamma-aminobutyric acid (GABA) tissue content associated with these signaling pathways, providing 1 potential biomarker to assess PFC changes with age. These highly coordinated pathway changes during aging may represent early steps for aging-related decline in PFC functions, such as learning and memory, and provide potential biomarkers to assess cognitive status in humans.

Identifiants

DOI: 10.1016/j.neurobiolaging.2023.08.009 PMID: 37797463
pubmed: 37797463
pii: S0197-4580(23)00208-7
doi: 10.1016/j.neurobiolaging.2023.08.009
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109-119

Subventions

Organisme : NIA NIH HHS
ID : U19 AG057758
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors report no conflicts of interest.

Auteurs

Laura A Cox (LA)

Center for Precision Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA; Section on Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA; Section on Comparative Medicine, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA. Electronic address: laurcox@wakehealth.edu.

Sobha Puppala (S)

Center for Precision Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA; Section on Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Jeannie Chan (J)

Center for Precision Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA; Section on Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Kip D Zimmerman (KD)

Center for Precision Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA; Section on Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Zeeshan Hamid (Z)

Center for Precision Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.

Isaac Ampong (I)

Center for Precision Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.

Hillary F Huber (HF)

Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.

Ge Li (G)

Center for Precision Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.

Avinash Y L Jadhav (AYL)

Center for Precision Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.

Benlian Wang (B)

Center for Precision Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.

Cun Li (C)

Texas Pregnancy & Life-Course Health Research Center, Department of Animal Science, University of Wyoming, Laramie, WY, USA.

Mark G Baxter (MG)

Section on Comparative Medicine, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Carol Shively (C)

Center for Precision Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA; Section on Comparative Medicine, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Geoffrey D Clarke (GD)

Department of Radiology, University of Texas Health Science Center, San Antonio, TX, USA.

Thomas C Register (TC)

Center for Precision Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA; Section on Comparative Medicine, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Peter W Nathanielsz (PW)

Texas Pregnancy & Life-Course Health Research Center, Department of Animal Science, University of Wyoming, Laramie, WY, USA.

Michael Olivier (M)

Center for Precision Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA; Section on Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Integrated multi-omics analysis of brain aging...
questionsmedicales.fr › Eucaryotes › Animaux › Integrated multi-omics analysis of brain aging...
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › Multi-omique › Integrated multi-omics analysis of brain aging...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Integrated multi-omics analysis of brain aging...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Integrated multi-omics analysis of brain aging...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe frontal › Cortex préfrontal › Integrated multi-omics analysis of brain aging...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Integrated multi-omics analysis of brain aging...