Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration.

Animals Humans Caenorhabditis elegans / metabolism Animals, Genetically Modified Parkinson Disease Antioxidants / metabolism Neurons
Bacterial toxin Caenorhabditis elegans Dopaminergic neurodegeneration Ferroptosis Parkinson’s disease Streptomyces venezuelae

Journal

Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270

Informations de publication

Date de publication:
10 2023
Historique:
received: 15 08 2023
revised: 14 09 2023
accepted: 22 09 2023
medline: 2 11 2023
pubmed: 6 10 2023
entrez: 5 10 2023
Statut: ppublish

Résumé

The causes of nigrostriatal cell death in idiopathic Parkinson's disease are unknown, but exposure to toxic chemicals may play some role. We followed up here on suggestions that bacterial secondary metabolites might be selectively cytotoxic to dopaminergic neurons. Extracts from Streptomyces venezuelae were found to kill human dopaminergic neurons (LUHMES cells). Utilizing this model system as a bioassay, we identified a bacterial metabolite known as aerugine (C

Identifiants

DOI: 10.1016/j.envint.2023.108229 PMID: 37797477 PMC: PMC10666548
pubmed: 37797477
pii: S0160-4120(23)00502-0
doi: 10.1016/j.envint.2023.108229
pmc: PMC10666548
mid: NIHMS1937915
pii:
doi:

Substances chimiques

Antioxidants 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108229

Subventions

Organisme : NIEHS NIH HHS
ID : R01 ES007331
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES010563
Pays : United States

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Auteurs

Anna-Katharina Ückert (AK)

In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, 78457 Konstanz, Germany.

Sina Rütschlin (S)

Department of Chemistry, Konstanz Research School Chemical Biology, Zukunftskolleg, University of Konstanz, 78457 Konstanz, Germany.

Simon Gutbier (S)

In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, 78457 Konstanz, Germany.

Nathalie Christine Wörz (NC)

Faculty of Chemistry, Institute for Biological Chemistry & Centre for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystems Science, University of Vienna, Josef-Holaubek-Platz 2 (UZA II), 1090 Vienna, Austria; Doctoral School in Chemistry (DoSChem), University of Vienna, 1090 Vienna, Austria.

Mahfuzur R Miah (MR)

Department of Molecular Pharmacology, Albert Einstein College of Medicine, 10641 Bronx, NY, United States.

Airton C Martins (AC)

Department of Molecular Pharmacology, Albert Einstein College of Medicine, 10641 Bronx, NY, United States; Department of Neuroscience, Albert Einstein College of Medicine, 10641 Bronx, NY, United States.

Isa Hauer (I)

In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, 78457 Konstanz, Germany.

Anna-Katharina Holzer (AK)

In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, 78457 Konstanz, Germany.

Birthe Meyburg (B)

In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, 78457 Konstanz, Germany.

Ann-Kathrin Mix (AK)

Lehrstuhl Zellbiologie, Universität Konstanz, Universitätsstraße 10, Postablage 621, 78457 Konstanz, Germany.

Christof Hauck (C)

Lehrstuhl Zellbiologie, Universität Konstanz, Universitätsstraße 10, Postablage 621, 78457 Konstanz, Germany.

Michael Aschner (M)

Department of Molecular Pharmacology, Albert Einstein College of Medicine, 10641 Bronx, NY, United States; Department of Neuroscience, Albert Einstein College of Medicine, 10641 Bronx, NY, United States.

Thomas Böttcher (T)

Department of Chemistry, Konstanz Research School Chemical Biology, Zukunftskolleg, University of Konstanz, 78457 Konstanz, Germany; Faculty of Chemistry, Institute for Biological Chemistry & Centre for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystems Science, University of Vienna, Josef-Holaubek-Platz 2 (UZA II), 1090 Vienna, Austria. Electronic address: thomas.boettcher@univie.ac.at.

Marcel Leist (M)

In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, 78457 Konstanz, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Identification of the bacterial metabolite...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of the bacterial metabolite...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › Identification of the bacterial metabolite...
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Animal génétiquement modifié › Identification of the bacterial metabolite...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Identification of the bacterial metabolite...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Identification of the bacterial metabolite...
questionsmedicales.fr › Cellules › Neurones › Identification of the bacterial metabolite...