Myo-inositol in assisted reproductive technology from bench to bedside.

Male Female Humans Inositol / therapeutic use Reproductive Techniques, Assisted Polycystic Ovary Syndrome / drug therapy Oocytes Insulin
D-chiro-inositol assisted reproductive technology in vitro fertilization infertility myo-inositol polycystic ovary syndrome

Journal

Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516

Informations de publication

Date de publication:
01 2024
Historique:
received: 05 05 2023
revised: 14 09 2023
accepted: 15 09 2023
medline: 11 1 2024
pubmed: 6 10 2023
entrez: 5 10 2023
Statut: ppublish

Résumé

Inositols are insulin-sensitizing compounds of promising efficacy in the management of polycystic ovary syndrome (PCOS). On the one hand, myo-inositol (myo-ins) plays a regulatory role in male and female reproductive function, influencing the development of oocytes, spermatozoa, and embryos. On the other hand, high concentrations of D-chiro-inositol (D-chiro-ins) in the ovary may adversely affect oocyte quality. This review analyses the available literature, which encourages the clinical use of myo-ins in assisted reproductive technologies (ARTs) due to its beneficial effects on female and male reproduction.

Identifiants

DOI: 10.1016/j.tem.2023.09.005 PMID: 37798243
pubmed: 37798243
pii: S1043-2760(23)00194-7
doi: 10.1016/j.tem.2023.09.005
pii:
doi:

Substances chimiques

Inositol 4L6452S749
Insulin 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

74-83

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests V.U. is employed at Lo.Li. Pharma Srl, Rome, Italy. All other authors have nothing to declare.

Auteurs

Andrea Etrusco (A)

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy; Unit of Obstetrics and Gynecology, 'Paolo Giaccone' Hospital, Palermo, Italy.

Antonio Simone Laganà (AS)

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy; Unit of Obstetrics and Gynecology, 'Paolo Giaccone' Hospital, Palermo, Italy; The Experts Group on Inositol in Basic and Clinical Research (EGOI).

Vito Chiantera (V)

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy; Unit of Gynecologic Oncology, National Cancer Institute - IRCCS - Fondazione 'G. Pascale', Naples, Italy.

Giovanni Buzzaccarini (G)

Obstetrics and Gynaecology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

Vittorio Unfer (V)

The Experts Group on Inositol in Basic and Clinical Research (EGOI); UniCamillus-Saint Camillus International University of Health Sciences, 00131 Rome, Italy. Electronic address: vunfer@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Myo-inositol in assisted reproductive...
questionsmedicales.fr › Glucides › Polyols › Inositol › Myo-inositol in assisted reproductive...
questionsmedicales.fr › Techniques d'investigation › Techniques de reproduction › Techniques de reproduction assistée › Myo-inositol in assisted reproductive...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Kystes de l'ovaire › Syndrome des ovaires polykystiques › Myo-inositol in assisted reproductive...
questionsmedicales.fr › Cellules › Cellules germinales › Ovocytes › Myo-inositol in assisted reproductive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Myo-inositol in assisted reproductive...