The expression of matrix metalloproteinase 2, 9 and 11 in Ethiopian breast cancer patients.
BC
Benign breast tumor
Ethiopia
Matrix metalloproteinases
mRNA expression
Journal
BMC research notes
ISSN: 1756-0500
Titre abrégé: BMC Res Notes
Pays: England
ID NLM: 101462768
Informations de publication
Date de publication:
05 Oct 2023
05 Oct 2023
Historique:
received:
28
02
2023
accepted:
19
09
2023
medline:
1
11
2023
pubmed:
6
10
2023
entrez:
5
10
2023
Statut:
epublish
Résumé
Matrix metalloproteinases (MMPs) play a pathophysiological role in cancer initiation and progression. Numerous studies have examined an association between MMP-2, MMP-9, and MMP-11 expression and clinicopathological characteristics of breast cancer (BC); however, no research has been done on the MMP expression levels in BC cases from Ethiopia. A total of 58 formalin-fixed paraffin-embedded breast tissue samples encompassing 16 benign breast tumors and 42 BC were collected. The RNA was extracted and quantitative reverse-transcription PCR was performed. GraphPad Prism version 8.0.0 was used for statistical analysis. The MMP-11 expression levels were significantly higher in breast cancer cases than in benign breast tumors (P = 0.012). Additionally, BC cases with positive lymph nodes and ER-positive receptors had higher MMP-11, MMP-9, and MMP-2 expression than cases with negative lymph nodes and ER-negative, respectively. The MMP-11 and MMP-9 expressions were higher in grade III and luminal A-like tumors than in grade I-II and other subtypes, respectively. The MMP-11 expression was higher in BC than in benign breast tumors. Additionally, MMP-11, MMP-9, and MMP-2 were higher in BC with positive lymph nodes and estrogen receptors. Our findings suggest an important impact of MMPs in BC pathophysiology, particularly MMP-11.
Identifiants
pubmed: 37798646
doi: 10.1186/s13104-023-06518-5
pii: 10.1186/s13104-023-06518-5
pmc: PMC10557335
doi:
Substances chimiques
Matrix Metalloproteinase 2
EC 3.4.24.24
Matrix Metalloproteinase 9
EC 3.4.24.35
Matrix Metalloproteinase 11
EC 3.4.24.-
Biomarkers, Tumor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
253Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
Références
PLoS One. 2021 May 26;16(5):e0252052
pubmed: 34038440
Prog Mol Biol Transl Sci. 2017;147:1-73
pubmed: 28413025
PLoS One. 2018 Aug 24;13(8):e0202113
pubmed: 30142200
Oncol Lett. 2017 Nov;14(5):5865-5870
pubmed: 29113219
APMIS. 2014 Dec;122(12):1196-206
pubmed: 24909183
Cell Death Discov. 2017 Aug 14;3:17036
pubmed: 28811933
Anticancer Res. 2019 Nov;39(11):5963-5971
pubmed: 31704821
J Clin Invest. 1996 Apr 15;97(8):1924-30
pubmed: 8621777
Mol Cell Biochem. 2019 Feb;452(1-2):111-121
pubmed: 30074136
BMC Cancer. 2009 Jun 16;9:188
pubmed: 19531263
Curr Genomics. 2006;7(8):497-508
pubmed: 18369406
Oral Health Prev Dent. 2019;17(6):505-514
pubmed: 31825023
Tumour Biol. 2001 Nov-Dec;22(6):383-9
pubmed: 11786732
Biochim Biophys Acta. 2012 Feb;1823(2):570-81
pubmed: 22227581
Med Oncol. 2013 Jun;30(2):562
pubmed: 23550278
J Mammary Gland Biol Neoplasia. 1996 Apr;1(2):231-40
pubmed: 10887496
Front Oncol. 2019 Dec 06;9:1370
pubmed: 31921634
Oncotarget. 2017 May 9;8(19):32309-32321
pubmed: 28427222
Breast Cancer Res. 2000;2(4):252-7
pubmed: 11250717
Nature. 1990 Dec 20-27;348(6303):699-704
pubmed: 1701851
Lab Invest. 2022 Apr;102(4):376-390
pubmed: 34775491
FEBS J. 2011 Jan;278(1):16-27
pubmed: 21087457
Clin Chim Acta. 2010 Feb;411(3-4):234-41
pubmed: 19914229
Dis Markers. 2013;34(6):395-405
pubmed: 23568046
PLoS One. 2015 Aug 13;10(8):e0135544
pubmed: 26270045
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1843-7
pubmed: 8446598
Nat Rev Cancer. 2002 Mar;2(3):161-74
pubmed: 11990853
Int J Cancer. 1996 Dec 20;69(6):448-51
pubmed: 8980245
Breast. 2013 Jun;22(3):330-4
pubmed: 22995648
Dis Markers. 2007;23(3):189-96
pubmed: 17473389
Clin Cancer Res. 2009 Jun 15;15(12):4104-13
pubmed: 19509157
Oncotarget. 2017 May 16;8(20):32783-32793
pubmed: 28427180
Breast Cancer Res Treat. 2020 Jul;182(2):267-282
pubmed: 32445177
J Transl Med. 2019 Jul 16;17(1):226
pubmed: 31311559
Int J Cancer. 2003 Sep 1;106(3):355-63
pubmed: 12845673
Oncol Rep. 2021 Apr;45(4):
pubmed: 33649832
Oncol Lett. 2021 Feb;21(2):78
pubmed: 33363615
Arch Gynecol Obstet. 2017 Mar;295(3):689-696
pubmed: 27995372
Circ Res. 2006 Jul 21;99(2):140-8
pubmed: 16778129