Gabapentin-Induced Cutaneous Leukocytoclastic Vasculitis: A Case Report.
gabapentin
hypersensitivity vasculitis
leukocytoclastic vasculitis
skin biopsy
small vessel vasculitis
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
accepted:
03
09
2023
medline:
6
10
2023
pubmed:
6
10
2023
entrez:
6
10
2023
Statut:
epublish
Résumé
Leukocytoclastic vasculitis (LCV) is a type of small vessel vasculitis, characterized by a perivascular neutrophilic inflammatory infiltrate with fibrinoid necrosis and fragmentation of nuclei ("leukocytoclasia"). Although up to half of the cases of LCV are idiopathic, infections and drugs are the most common secondary triggers for this condition. We present the case of an 88-year-old woman who developed an erythematous maculopapular rash on both thighs three days after starting gabapentin for neuropathic leg pain, without other associated symptoms. Skin biopsy was compatible with cutaneous vasculitis with a leukocytoclastic pattern. The skin lesions resolved within about 10 days after discontinuing gabapentin, supporting the diagnosis. To our knowledge, there are only four published cases of LCV secondary to gabapentin. This case highlights the importance of being alert for diagnosing drug-related cutaneous manifestations, even if the drug is used in our daily practice and vasculitis is not a common side effect, since discontinuing the suspected agent is crucial to resolve skin lesions and to avoid more serious complications.
Identifiants
pubmed: 37799214
doi: 10.7759/cureus.44616
pmc: PMC10547605
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e44616Informations de copyright
Copyright © 2023, Órfão et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Intern Emerg Med. 2021 Jun;16(4):831-841
pubmed: 33713282
J Int Med Res. 2022 May;50(5):3000605221097768
pubmed: 35587703
Therapie. 2014 Sep-Oct;69(5):469-71
pubmed: 27392884
Singapore Med J. 2003 Jan;44(1):42-4
pubmed: 12762564
Am J Med. 1997 Feb;102(2):186-91
pubmed: 9217569
Hum Pathol. 1979 May;10(3):313-25
pubmed: 468217
Arthritis Rheum. 2013 Jan;65(1):1-11
pubmed: 23045170
Int J Low Extrem Wounds. 2004 Sep;3(3):123-4
pubmed: 15866802
Clin Pharmacol Ther. 1981 Aug;30(2):239-45
pubmed: 7249508
Arthritis Rheum. 1990 Aug;33(8):1108-13
pubmed: 2202309
IDCases. 2019 Apr 17;17:e00539
pubmed: 31384556
Arthritis Rheumatol. 2018 Feb;70(2):171-184
pubmed: 29136340
Ann Pharmacother. 2009 Feb;43(2):387-9
pubmed: 19193587
Clin Rev Allergy Immunol. 2021 Oct;61(2):181-193
pubmed: 32378145
Clin Neuropharmacol. 2008 Mar-Apr;31(2):93-6
pubmed: 18382181
Cureus. 2020 May 1;12(5):e7912
pubmed: 32494527