A systematic review and meta-analysis of neopterin in rheumatic diseases.
biomarkers
inflammation
metabolism
neopterin
oxidative stress
rheumatic diseases
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
08
2023
accepted:
04
09
2023
medline:
9
10
2023
pubmed:
6
10
2023
entrez:
6
10
2023
Statut:
epublish
Résumé
Novel biomarkers of inflammation and oxidative stress might enhance the early recognition, management, and clinical outcomes of patients with rheumatic diseases (RDs). We assessed the available evidence regarding the pathophysiological role of neopterin, the oxidation product of 7,8-dihydroneopterin, a pteridine generated in macrophages activated by interferon-γ, by conducting a systematic review and meta-analysis of studies reporting its concentrations in biological fluids in RD patients and healthy controls. We searched electronic databases for relevant articles published between inception and 31 August 2023. The risk of bias and the certainty of evidence were assessed using the Joanna Briggs Institute Critical Appraisal Checklist and the Grades of Recommendation, Assessment, Development and Evaluation Working Group system, respectively. In 37 studies, when compared to healthy controls, RD patients had significantly higher concentrations of neopterin both in plasma or serum (standard mean difference, SMD=1.31, 95% CI 1.01 to 1.61; p<0.001; moderate certainty of evidence) and in the urine (SMD=1.65, 95% CI 0.86 to 2.43, p<0.001; I Pending additional studies that also focus on early forms of disease, our systematic review and meta-analysis supports the proposition that neopterin, a biomarker of inflammation and oxidative stress, can be useful for the identification of RDs. (PROSPERO registration number: CRD42023450209). PROSPERO, identifier CRD42023450209.
Identifiants
pubmed: 37799718
doi: 10.3389/fimmu.2023.1271383
pmc: PMC10548830
doi:
Substances chimiques
Neopterin
670-65-5
Biomarkers
0
Types de publication
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1271383Informations de copyright
Copyright © 2023 Mangoni and Zinellu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision
Références
Ann Rheum Dis. 2011 Jul;70(7):1292-5
pubmed: 21515600
Free Radic Res. 2001 Feb;34(2):123-36
pubmed: 11264890
Immunology. 2009 Mar;126(3):386-93
pubmed: 18759749
BMJ. 2003 Sep 6;327(7414):557-60
pubmed: 12958120
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 15;863(1):167-71
pubmed: 18234568
Nat Rev Rheumatol. 2021 Nov;17(11):678-691
pubmed: 34611329
Clin Chim Acta. 1991 Sep 14;201(1-2):1-16
pubmed: 1790613
Clin Rheumatol. 2012 Jan;31(1):29-34
pubmed: 21556779
J Clin Epidemiol. 2011 Apr;64(4):401-6
pubmed: 21208779
Stat Med. 2002 Jun 15;21(11):1539-58
pubmed: 12111919
Lupus. 2016 Mar;25(3):282-8
pubmed: 26405019
Clin Rheumatol. 2017 Sep;36(9):1975-1979
pubmed: 27699655
Int J Biochem Cell Biol. 2017 Jun;87:27-33
pubmed: 28356230
J Exp Med. 1984 Jul 1;160(1):310-6
pubmed: 6429267
Med J Aust. 2017 Mar 20;206(5):192-194
pubmed: 28301782
J Transl Autoimmun. 2021 Oct 28;4:100129
pubmed: 35005593
Exp Gerontol. 2017 Dec 1;99:133-137
pubmed: 29024722
Autoimmunity. 2013 Feb;46(1):44-9
pubmed: 22978451
Scand J Rheumatol. 2003;32(2):74-8
pubmed: 12737324
Ther Adv Musculoskelet Dis. 2022 Sep 3;14:1759720X221117880
pubmed: 36081748
Clin Chem. 1994 Feb;40(2):265-6
pubmed: 8313604
Eur J Biochem. 1987 Jul 15;166(2):303-10
pubmed: 3301338
Nat Rev Nephrol. 2017 Aug;13(8):483-495
pubmed: 28669995
Aust Prescr. 2015 Jun;38(3):93-4
pubmed: 26648629
Free Radic Res. 1995 Aug;23(2):123-36
pubmed: 7581810
Rheumatol Int. 1998;18(3):107-11
pubmed: 9833251
Clin Biochem. 2015 Jan;48(1-2):63-9
pubmed: 25179377
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5545-50
pubmed: 11960012
J Clin Invest. 2007 Apr;117(4):871-3
pubmed: 17404615
Biometrics. 1994 Dec;50(4):1088-101
pubmed: 7786990
Lupus. 2017 Dec;26(14):1534-1539
pubmed: 28530466
BMJ. 2021 Mar 29;372:n71
pubmed: 33782057
Adv Immunol. 2007;96:41-101
pubmed: 17981204
F1000Prime Rep. 2014 Mar 03;6:13
pubmed: 24669294
Biomed Pharmacother. 2022 Jul;151:113126
pubmed: 35643074
Horm Mol Biol Clin Investig. 2021 Jul 26;42(4):419-423
pubmed: 34303320
Anal Biochem. 1980 Feb;102(1):176-88
pubmed: 7356152
J Eur Acad Dermatol Venereol. 2009 Dec;23(12):1414-8
pubmed: 19522774
J Clin Immunol. 1994 Nov;14(6):368-74
pubmed: 7883864
BMJ. 2015 Nov 26;351:h5079
pubmed: 26612523
Lancet. 2011 Jan 8;377(9760):108-9
pubmed: 20630580
Ann Rheum Dis. 2017 Jan;76(1):166-172
pubmed: 27296321
BMC Med Res Methodol. 2014 Dec 19;14:135
pubmed: 25524443
Biometrics. 2000 Jun;56(2):455-63
pubmed: 10877304
Clin Exp Immunol. 1988 Dec;74(3):392-7
pubmed: 3148378
Ann Rheum Dis. 1989 Aug;48(8):636-40
pubmed: 2782974
Ann Rheum Dis. 1993 Jun;52(6):429-35
pubmed: 8323394
Hum Immunol. 2000 Sep;61(9):863-6
pubmed: 11053629
Arthritis Care Res (Hoboken). 2011 Apr;63(4):535-41
pubmed: 20890983
BMC Med Res Methodol. 2005 Apr 20;5:13
pubmed: 15840177
Biochem Biophys Res Commun. 2004 Aug 20;321(2):379-85
pubmed: 15358187
Dermatol Ther. 2020 Jul;33(4):e13443
pubmed: 32307820
Free Radic Biol Med. 2020 May 20;152:142-151
pubmed: 32145301
Expert Rev Clin Immunol. 2018 Mar;14(3):171-173
pubmed: 29338450
Clin Chem. 1990 Apr;36(4):705-6
pubmed: 2323057
Clin Rheumatol. 2019 Oct;38(10):2727-2736
pubmed: 31161488
Rheumatol Adv Pract. 2021 Dec 28;6(1):rkab106
pubmed: 35005426
Clin Biochem. 2002 Nov;35(8):633-9
pubmed: 12498998
J Gerontol A Biol Sci Med Sci. 2010 Aug;65(8):858-65
pubmed: 20478905
FEBS Lett. 1993 Aug 23;329(1-2):13-6
pubmed: 8354387
Int J Dermatol. 1986 May;25(4):235-9
pubmed: 3710672
Scand J Rheumatol. 1986;15(2):148-52
pubmed: 3749827
Biochim Biophys Acta. 2002 Aug 19;1591(1-3):139-145
pubmed: 12183064
Immunol Invest. 2019 May;48(4):367-377
pubmed: 30513021
Cancer Discov. 2016 Jun;6(6):664-79
pubmed: 27076371
Arch Rheumatol. 2016 Apr 14;31(4):333-339
pubmed: 30375574
Antioxidants (Basel). 2018 Jun 26;7(7):
pubmed: 29949851
Immunobiology. 2018 Jan;223(1):101-111
pubmed: 29032836
RMD Open. 2022 Feb;8(1):
pubmed: 35135860
J Leukoc Biol. 2004 Feb;75(2):163-89
pubmed: 14525967
Trends Immunol. 2008 Oct;29(10):479-86
pubmed: 18775671
Redox Rep. 2003;8(2):113-5
pubmed: 12804014
J Biochem Biophys Methods. 2004 Jun 30;59(3):275-83
pubmed: 15165758
Acta Medica (Hradec Kralove). 1999;42(3):97-101
pubmed: 10677896
J Rheumatol. 1999 Apr;26(4):966-70
pubmed: 10229429
Lupus. 2011 May;20(6):588-97
pubmed: 21436216
Clin Chem Lab Med. 2000 Apr;38(4):345-53
pubmed: 10928656
Nat Rev Rheumatol. 2016 May;12(5):269-81
pubmed: 26935283
J Clin Epidemiol. 2001 Oct;54(10):1046-55
pubmed: 11576817
Biomed Chromatogr. 2004 Jul;18(6):360-6
pubmed: 15273976
Biochem Biophys Res Commun. 2000 Aug 28;275(2):307-11
pubmed: 10964663
PLoS Med. 2006 Aug;3(8):e297
pubmed: 16942393
Lupus. 2016 Jun;25(7):710-8
pubmed: 26703437
Cell. 2020 Apr 2;181(1):63-80
pubmed: 32243797
Clin Rheumatol. 2005 Apr;24(2):107-10
pubmed: 15818511
Biomed Pharmacother. 2022 Nov;155:113683
pubmed: 36095965
Br J Rheumatol. 1997 Jun;36(6):656-60
pubmed: 9236675
Eur J Dermatol. 2010 Jan-Feb;20(1):35-41
pubmed: 19919906
Sci Rep. 2022 Nov 3;12(1):18599
pubmed: 36329101
Ann Rheum Dis. 2002 Jan;61(1):79-81
pubmed: 11779767
Inflamm Regen. 2022 Dec 2;42(1):37
pubmed: 36457027
J Am Geriatr Soc. 1994 Jul;42(7):738-42
pubmed: 8014349
Cytokine. 2016 Sep;85:14-7
pubmed: 27269180
Clin Chem Lab Med. 2007;45(1):73-7
pubmed: 17243919
Clin Biochem. 2005 Feb;38(2):134-41
pubmed: 15642275
Lupus. 2012 May;21(6):616-24
pubmed: 22323339
Immune Netw. 2022 Feb 17;22(1):e9
pubmed: 35291650
Clin Chem. 1991 Jan;37(1):47-50
pubmed: 1988207
Clin Exp Immunol. 2020 Mar;199(3):314-325
pubmed: 31797350
Clin Rheumatol. 2018 Apr;37(4):971-977
pubmed: 29273831
Immunology. 2015 Nov;146(3):470-85
pubmed: 26288256
Am J Clin Dermatol. 2019 Aug;20(4):539-564
pubmed: 30997665
Clin Rheumatol. 2000;19(4):328-9
pubmed: 10941821
Cell Immunol. 2001 Jul 10;211(1):43-50
pubmed: 11585387
Clin Rheumatol. 2015 Aug;34(8):1327-31
pubmed: 25711876
Skinmed. 2005 Sep-Oct;4(5):282-6
pubmed: 16282749
J Autoimmun. 2023 May;137:102999
pubmed: 36720662
Clin Med (Lond). 2020 Nov;20(6):561-564
pubmed: 33199320
J Dermatol Sci. 2006 May;42(2):128-30
pubmed: 16600572
Immunobiology. 2018 Aug - Sep;223(8-9):526-535
pubmed: 29605258
Clin Exp Rheumatol. 1995 Mar-Apr;13(2):269-70
pubmed: 7656478