The molecular mechanisms of diapause and diapause-like reversible arrest.
chemotherapy
diapause
dormancy
germline stem cell
quiescence
stem cell self-renewal
Journal
Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897
Informations de publication
Date de publication:
31 10 2023
31 10 2023
Historique:
received:
26
06
2023
revised:
12
09
2023
accepted:
25
09
2023
medline:
1
11
2023
pubmed:
6
10
2023
entrez:
6
10
2023
Statut:
ppublish
Résumé
Diapause is a protective mechanism that many organisms deploy to overcome environmental adversities. Diapause extends lifespan and fertility to enhance the reproductive success and survival of the species. Although diapause states have been known and employed for commercial purposes, for example in the silk industry, detailed molecular and cell biological studies are an exciting frontier. Understanding diapause-like protective mechanisms will shed light on pathways that steer organisms through adverse conditions. One hope is that an understanding of the mechanisms that support diapause might be leveraged to extend the lifespan and/or health span of humans as well as species threatened by climate change. In addition, recent findings suggest that cancer cells that persist after treatment mimic diapause-like states, implying that these programs may facilitate cancer cell survival from chemotherapy and cause relapse. Here, we review the molecular mechanisms underlying diapause programs in a variety of organisms, and we discuss pathways supporting diapause-like states in tumor persister cells.
Identifiants
pubmed: 37800560
pii: 233599
doi: 10.1042/BST20221431
pmc: PMC10657177
doi:
Types de publication
Review
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1847-1856Subventions
Organisme : NIA NIH HHS
ID : R01 AG033607
Pays : United States
Informations de copyright
© 2023 The Author(s).
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