"We've got to get out"-Strategies of human pathogenic fungi to escape from phagocytes.
host cell exit
host-pathogen interactions
human fungal pathogens
immune evasion
macrophages
Journal
Molecular microbiology
ISSN: 1365-2958
Titre abrégé: Mol Microbiol
Pays: England
ID NLM: 8712028
Informations de publication
Date de publication:
06 Oct 2023
06 Oct 2023
Historique:
revised:
08
08
2023
received:
30
06
2023
accepted:
16
08
2023
medline:
6
10
2023
pubmed:
6
10
2023
entrez:
6
10
2023
Statut:
aheadofprint
Résumé
Human fungal pathogens are a deadly and underappreciated risk to global health that most severely affect immunocompromised individuals. A virulence attribute shared by some of the most clinically relevant fungal species is their ability to survive inside macrophages and escape from these immune cells. In this review, we discuss the mechanisms behind intracellular survival and elaborate how escape is mediated by lytic and non-lytic pathways as well as strategies to induce programmed host cell death. We also discuss persistence as an alternative to rapid host cell exit. In the end, we address the consequences of fungal escape for the host immune response and provide future perspectives for research and development of targeted therapies.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : EXC 2051
Organisme : Deutsche Forschungsgemeinschaft
ID : SPP 2225
Organisme : Deutsche Forschungsgemeinschaft
ID : TRR 124
Organisme : HORIZON EUROPE Framework Programme
ID : 812969
Organisme : HORIZON EUROPE Framework Programme
ID : 847507
Informations de copyright
© 2023 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd.
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