SarS and Rot are necessary for the repression of

The leukocidins play an important role in disarming the host immune system and promoting infection. While both SarS and Rot have been established as repressors of leukocidins, the importance of each repressor in infection is unclear. Here, we demonstrate that repression by SarS and Rot is not additive and show that in addition to upregulating expression of each other, they are also able to bind concurrently to the leukocidin promoters. These findings suggest that both repressors are necessary for maximal repression of

Déclaration de conflit d'intérêts

V.J.T. is an inventor on patents and patent applications filed by New York University, which are currently under commercial license to Janssen Biotech, Inc. Janssen Biotech, Inc., provides research funding and other payments associated with the licensing agreement. All other authors declare no conflicts of interest.