Effect of Physical Exercise on MRI-Assessed Brain Perfusion in Chemotherapy-Treated Breast Cancer Patients: A Randomized Controlled Trial.
breast cancer
cerebral blood flow
cognition
exercise
memory
physical fitness
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
06 Oct 2023
06 Oct 2023
Historique:
revised:
01
08
2023
received:
30
03
2023
accepted:
02
08
2023
medline:
6
10
2023
pubmed:
6
10
2023
entrez:
6
10
2023
Statut:
aheadofprint
Résumé
Exercise is a promising intervention to alleviate cognitive problems in breast cancer patients, but studies on mechanisms underlying these effects are lacking. Investigating whether an exercise intervention can affect cerebral blood flow (CBF) in cognitively impaired breast cancer patients and to determine if CBF changes relate to memory function. Prospective. A total of 181 chemotherapy-treated stage I-III breast cancer patients with cognitive problems and relatively low physical activity levels (≤150 minutes moderate to vigorous physical activity per week), divided into an exercise (N = 91) or control group (N = 90). Two-dimensional echo planar pseudo-continuous arterial spin labeling CBF sequence at 3 T. The 6-month long intervention consisted of (supervised) aerobic and strength training, 4 × 1 hour/week. Measurements at baseline (2-4 years post-diagnosis) and after 6 months included gray matter CBF in the whole brain, hippocampus, anterior cingulate cortex, and posterior cingulate cortex. Physical fitness and memory function were also assessed. Subgroup analyses were performed in patients with high fatigue levels at baseline. Multiple regression analyses with a two-sided alpha of 0.05 for all analyses. There was a significant improvement in physical fitness (VO The exercise intervention did not affect CBF of cognitively affected breast cancer patients. A change in physical fitness was associated with changes in CBF, but changes in CBF were not associated with memory functioning. 1 TECHNICAL EFFICACY STAGE: 5.
Sections du résumé
BACKGROUND
BACKGROUND
Exercise is a promising intervention to alleviate cognitive problems in breast cancer patients, but studies on mechanisms underlying these effects are lacking.
PURPOSE
OBJECTIVE
Investigating whether an exercise intervention can affect cerebral blood flow (CBF) in cognitively impaired breast cancer patients and to determine if CBF changes relate to memory function.
STUDY TYPE
METHODS
Prospective.
POPULATION
METHODS
A total of 181 chemotherapy-treated stage I-III breast cancer patients with cognitive problems and relatively low physical activity levels (≤150 minutes moderate to vigorous physical activity per week), divided into an exercise (N = 91) or control group (N = 90).
FIELD STRENGTH/SEQUENCE
UNASSIGNED
Two-dimensional echo planar pseudo-continuous arterial spin labeling CBF sequence at 3 T.
ASSESSMENT
RESULTS
The 6-month long intervention consisted of (supervised) aerobic and strength training, 4 × 1 hour/week. Measurements at baseline (2-4 years post-diagnosis) and after 6 months included gray matter CBF in the whole brain, hippocampus, anterior cingulate cortex, and posterior cingulate cortex. Physical fitness and memory function were also assessed. Subgroup analyses were performed in patients with high fatigue levels at baseline.
STATISTICAL TESTS
METHODS
Multiple regression analyses with a two-sided alpha of 0.05 for all analyses.
RESULTS
RESULTS
There was a significant improvement in physical fitness (VO
DATA CONCLUSION
CONCLUSIONS
The exercise intervention did not affect CBF of cognitively affected breast cancer patients. A change in physical fitness was associated with changes in CBF, but changes in CBF were not associated with memory functioning.
LEVEL OF EVIDENCE
METHODS
1 TECHNICAL EFFICACY STAGE: 5.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : KWF kankerbestrijding
ID : UU 2015-7954
Informations de copyright
© 2023 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
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