Regulatory role of human endometrial gland secretome on macrophage differentiation.
Cytokine
Endometrial gland
Macrophage
Organoid
Phagocytosis
Journal
Journal of reproductive immunology
ISSN: 1872-7603
Titre abrégé: J Reprod Immunol
Pays: Ireland
ID NLM: 8001906
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
20
07
2023
revised:
24
08
2023
accepted:
29
09
2023
medline:
5
12
2023
pubmed:
7
10
2023
entrez:
6
10
2023
Statut:
ppublish
Résumé
The human endometrial gland plays a vital role in maternal immune tolerance and placental development. Decidual macrophages are the major phagocytic cells that regulate tissue remodeling during pregnancy. This study examines the regulatory effect of endometrial gland secretome on macrophage polarization and functions using endometrial organoid. We demonstrated that endometrial organoids treated with hormones mimicking the environment of the secretory phase/early pregnancy polarize macrophages to acquire a decidua-like macrophage phenotype, including higher expressions of decidual macrophage markers, reduced phagocytic capacity and altered cytokine secretion. The results indicated that endometrial gland secretomes are critical for maintaining macrophage homeostasis at the maternal-fetal interface.
Identifiants
pubmed: 37801890
pii: S0165-0378(23)00364-9
doi: 10.1016/j.jri.2023.104158
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104158Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.