Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer's disease-like neuroinflammation triggered by periodontal disease.
Antimicrobial therapy
Brain microbiome
Neuroinflammation
Nisin
Oral microbiome
Periodontal disease
Journal
Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974
Informations de publication
Date de publication:
06 Oct 2023
06 Oct 2023
Historique:
received:
06
05
2023
accepted:
28
09
2023
medline:
1
11
2023
pubmed:
7
10
2023
entrez:
6
10
2023
Statut:
epublish
Résumé
Periodontitis-related oral microbial dysbiosis is thought to contribute to Alzheimer's disease (AD) neuroinflammation and brain amyloid production. Since probiotics can modulate periodontitis/oral dysbiosis, this study examined the effects of a probiotic/lantibiotic, nisin, in modulating brain pathology triggered by periodontitis. A polymicrobial mouse model of periodontal disease was used to evaluate the effects of this disease on brain microbiome dysbiosis, neuroinflammation, Alzheimer's-related changes, and nisin's therapeutic potential in this context. 16S sequencing and real-time PCR data revealed that Nisin treatment mitigated the changes in the brain microbiome composition, diversity, and community structure, and reduced the levels of periodontal pathogen DNA in the brain induced by periodontal disease. Nisin treatment significantly decreased the mRNA expression of pro-inflammatory cytokines (Interleukin-1β/IL-1 β, Interleukin 6/IL-6, and Tumor Necrosis Factor α/TNF-α) in the brain that were elevated by periodontal infection. In addition, the concentrations of amyloid-β 42 (Aβ42), total Tau, and Tau (pS199) (445.69 ± 120.03, 1420.85 ± 331.40, 137.20 ± 36.01) were significantly higher in the infection group compared to the control group (193.01 ± 31.82, 384.27 ± 363.93, 6.09 ± 10.85), respectively. Nisin treatment markedly reduced the Aβ42 (261.80 ± 52.50), total Tau (865.37 ± 304.93), and phosphorylated Tau (82.53 ± 15.77) deposition in the brain of the infection group. Nisin abrogation of brain microbiome dysbiosis induces beneficial effects on AD-like pathogenic changes and neuroinflammation, and thereby may serve as a potential therapeutic for periodontal-dysbiosis-related AD.
Identifiants
pubmed: 37803465
doi: 10.1186/s12974-023-02915-6
pii: 10.1186/s12974-023-02915-6
pmc: PMC10557354
doi:
Substances chimiques
nisin A
EN8XKG133D
Nisin
1414-45-5
Bacteriocins
0
Amyloid beta-Peptides
0
Interleukin-6
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
228Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE025225
Pays : United States
Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
Références
J Membr Biol. 1996 Jun;151(3):293-300
pubmed: 8661516
J Periodontol. 2012 Dec;83(12):1508-19
pubmed: 22376207
J Alzheimers Dis. 2013;36(4):665-77
pubmed: 23666172
J Biol Chem. 2001 Jan 19;276(3):1772-9
pubmed: 11038353
Neurobiol Aging. 2015 Feb;36(2):627-33
pubmed: 25491073
PLoS Pathog. 2021 Jul 13;17(7):e1009311
pubmed: 34255809
Nature. 2020 Apr;580(7801):130-135
pubmed: 32238926
Biophys J. 1999 Aug;77(2):842-52
pubmed: 10423430
Front Cell Infect Microbiol. 2021 May 19;11:671968
pubmed: 34094999
Neurol Clin. 2016 Nov;34(4):941-953
pubmed: 27720002
J Bacteriol. 2001 Jun;183(12):3770-83
pubmed: 11371542
Res Microbiol. 1998 Jan;149(1):31-7
pubmed: 9766207
Odontology. 2006 Sep;94(1):10-21
pubmed: 16998613
Neurobiol Aging. 2000 May-Jun;21(3):383-421
pubmed: 10858586
Alzheimers Dement. 2008 Jul;4(4):242-50
pubmed: 18631974
Clin Dev Immunol. 2013;2013:503754
pubmed: 23762091
J Neuroinflammation. 2018 Feb 09;15(1):37
pubmed: 29426327
J Physiol. 2017 Jan 15;595(2):465-476
pubmed: 27426277
Neurobiol Aging. 2004 Apr;25(4):419-29
pubmed: 15013562
J Bacteriol. 1998 Dec;180(24):6565-70
pubmed: 9852000
Transfus Apher Sci. 2008 Oct;39(2):173-8
pubmed: 18753008
PLoS Pathog. 2014 Mar 27;10(3):e1003933
pubmed: 24676390
J Alzheimers Dis. 2017;58(2):337-348
pubmed: 28453484
J Alzheimers Dis. 2015;43(1):67-80
pubmed: 25061055
Oncol Rep. 2012 Oct;28(4):1362-8
pubmed: 22797782
Front Cell Neurosci. 2014 Apr 22;8:112
pubmed: 24795567
J Oral Microbiol. 2020 Aug 24;12(1):1809302
pubmed: 32944159
Science. 1999 Dec 17;286(5448):2361-4
pubmed: 10600751
J Clin Periodontol. 2013 Apr;40 Suppl 14:S20-3
pubmed: 23627330
Infect Immun. 2011 Feb;79(2):806-11
pubmed: 21115719
Mol Oral Microbiol. 2011 Aug;26(4):229-40
pubmed: 21729244
Protein Pept Lett. 2014 Apr;21(4):399-406
pubmed: 24164260
J Alzheimers Dis. 2009;16(2):341-50
pubmed: 19221424
Infect Immun. 1996 Jun;64(6):2094-100
pubmed: 8675312
PLoS One. 2014 Dec 18;9(12):e114959
pubmed: 25522313
J Appl Microbiol. 2016 Jun;120(6):1449-65
pubmed: 26678028
Lancet Neurol. 2015 Apr;14(4):388-405
pubmed: 25792098
Biomaterials. 2021 Aug;275:120942
pubmed: 34147718
Sci Adv. 2019 Jan 23;5(1):eaau3333
pubmed: 30746447
J Pept Sci. 2011 Jun;17(6):438-44
pubmed: 21294231
NPJ Biofilms Microbiomes. 2022 Jun 7;8(1):45
pubmed: 35672331
Immun Ageing. 2018 Jan 30;15:6
pubmed: 29422938
J Periodontol. 2015 May;86(5):611-22
pubmed: 25688694
Alzheimers Dement. 2012 May;8(3):196-203
pubmed: 22546352
Innate Immun. 2013 Jun;19(3):315-27
pubmed: 23109507
J Neuroimmunol. 2009 Nov 30;216(1-2):92-7
pubmed: 19767111
Front Aging Neurosci. 2017 Dec 01;9:398
pubmed: 29249963
Nat Rev Neurol. 2013 Jan;9(1):25-34
pubmed: 23183882
NPJ Biofilms Microbiomes. 2020 Mar 10;6(1):10
pubmed: 32157085
Periodontol 2000. 2021 Oct;87(1):11-16
pubmed: 34463994
Oral Microbiol Immunol. 2002 Apr;17(2):113-8
pubmed: 11929559
PLoS One. 2018 Oct 3;13(10):e0204941
pubmed: 30281647
J Oral Microbiol. 2017 Jan 17;9(1):1270602
pubmed: 28326151
Neurosci Insights. 2021 May 27;16:26331055211018709
pubmed: 34104888
Am J Pathol. 2008 Nov;173(5):1415-27
pubmed: 18832582
Front Aging Neurosci. 2014 Jun 16;6:127
pubmed: 24982633
Cell Biol Int. 2019 Jun;43(6):582-592
pubmed: 30958602
Microbiome. 2020 Jun 30;8(1):103
pubmed: 32605663
Neuroreport. 1999 May 14;10(7):1489-91
pubmed: 10380968
Int J Clin Exp Pathol. 2015 Feb 01;8(2):2214-20
pubmed: 25973132
Trends Microbiol. 2003 Feb;11(2):94-100
pubmed: 12598132
Asian Pac J Cancer Prev. 2018 Aug 24;19(8):2217-2222
pubmed: 30139228
Brain Behav Immun. 2017 Oct;65:350-361
pubmed: 28610747
Cell Microbiol. 2018 Apr;20(4):
pubmed: 29205773
J Periodontol. 2000 Oct;71(10):1528-34
pubmed: 11063384
NPJ Aging Mech Dis. 2017 Nov 6;3:15
pubmed: 29134111
PLoS Pathog. 2020 Oct 1;16(10):e1008881
pubmed: 33002094
Front Microbiol. 2015 Jun 18;6:617
pubmed: 26150809
J Appl Oral Sci. 2016 Jul-Aug;24(4):352-8
pubmed: 27556206
Curr Infect Dis Rep. 2017 Feb;19(2):9
pubmed: 28233191
Dent Clin North Am. 2015 Oct;59(4):885-917
pubmed: 26427573
Expert Rev Mol Med. 2011 Sep 20;13:e30
pubmed: 21933454
J Alzheimers Dis. 2016;51(4):979-84
pubmed: 26967229