Longitudinal associations between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and nutritional status in older adults from the MAPT study.

BACKGROUND

Weight and appetite regulation have been associated with the expression and secretion of ATPase inhibitory factor 1 (IF1) and growth-differentiation factor-15 (GDF-15), two potential biomarkers for age-related mitochondrial dysfunction. The aim was to explore the associations between these biomarkers and nutritional variables in the MAPT study.

METHODS

IF1 and GDF-15 plasma levels were quantified at one-year follow-up. The nutritional status was measured using the Mini Nutritional Assessment (MNA) score variation between baseline and 1- and 2-year visits; appetite loss was extracted from the MNA. Bodyweight was measured every six months until the third year and then yearly until the fifth year of follow-up, and weight loss was established if the loss was greater than 5 or 10 percent within the past 6 or 12 months, respectively. Bidirectional associations of IF1 and GDF-15 levels with malnutrition, appetite and weight loss were examined. The interactions between individual IF1 and GDF-15 with sex were explored.

RESULTS

448 participants had MNA data and 1045 had weight loss data. All the associations between IF1 levels and the MNA score, appetite loss, and weight loss were non-significant. Higher GDF-15 levels were cross-sectionally associated with appetite loss at the first year of follow-up, and the GDF-15 highest quartile was associated with nearly 80% higher risks of weight loss over four years. Interactions between IF1 and GDF-15 levels, and between these two markers and sex were not significantly associated with the outcomes.

CONCLUSION

GDF-15 plasma levels were related to key malnutrition criteria.

Informations de copyright

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