Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries.

Amino acids Dietary protein Haemorrhagic stroke Ischaemic stroke Nutritional epidemiology Prospective cohort

Journal

European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704

Informations de publication

Date de publication:
07 Oct 2023
Historique:
received: 31 03 2023
accepted: 08 09 2023
medline: 7 10 2023
pubmed: 7 10 2023
entrez: 7 10 2023
Statut: aheadofprint

Résumé

Previously reported associations of protein-rich foods with stroke subtypes have prompted interest in the assessment of individual amino acids. We examined the associations of dietary amino acids with risks of ischaemic and haemorrhagic stroke in the EPIC study. We analysed data from 356,142 participants from seven European countries. Dietary intakes of 19 individual amino acids were assessed using validated country-specific dietary questionnaires, calibrated using additional 24-h dietary recalls. Multivariable-adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of ischaemic and haemorrhagic stroke in relation to the intake of each amino acid. The role of blood pressure as a potential mechanism was assessed in 267,642 (75%) participants. After a median follow-up of 12.9 years, 4295 participants had an ischaemic stroke and 1375 participants had a haemorrhagic stroke. After correction for multiple testing, a higher intake of proline (as a percent of total protein) was associated with a 12% lower risk of ischaemic stroke (HR per 1 SD higher intake 0.88; 95% CI 0.82, 0.94). The association persisted after mutual adjustment for all other amino acids, systolic and diastolic blood pressure. The inverse associations of isoleucine, leucine, valine, phenylalanine, threonine, tryptophan, glutamic acid, serine and tyrosine with ischaemic stroke were each attenuated with adjustment for proline intake. For haemorrhagic stroke, no statistically significant associations were observed in the continuous analyses after correcting for multiple testing. Higher proline intake may be associated with a lower risk of ischaemic stroke, independent of other dietary amino acids and blood pressure.

Identifiants

pubmed: 37804448
doi: 10.1007/s00394-023-03251-4
pii: 10.1007/s00394-023-03251-4
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Council
ID : MR/M012190/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C8221/A19170
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 570/A16491
Pays : United Kingdom
Organisme : Wellcome Trust
ID : Our Planet Our Health
Pays : United Kingdom
Organisme : Wellcome Trust
ID : Livestock Environment
Pays : United Kingdom
Organisme : Wellcome Trust
ID : People 205212/Z/16/Z
Pays : United Kingdom

Informations de copyright

© 2023. The Author(s).

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Auteurs

Tammy Y N Tong (TYN)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK. tammy.tong@ndph.ox.ac.uk.

Robert Clarke (R)

Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Julie A Schmidt (JA)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK.
Departments of Clinical Epidemiology, Clinical Medicine, Aarhus University Hospital and Aarhus University, Aarhus, Denmark.

Inge Huybrechts (I)

Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), World Health Organization (WHO), Lyon, France.

Urwah Noor (U)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK.

Nita G Forouhi (NG)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.

Fumiaki Imamura (F)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.

Ruth C Travis (RC)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK.

Elisabete Weiderpass (E)

International Agency for Research on Cancer (IARC), World Health Organization (WHO), Lyon, France.

Krasimira Aleksandrova (K)

Department Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany.
Faculty of Human and Health Sciences, University of Bremen, Grazer Straße 2, 28359, Bremen, Germany.

Christina C Dahm (CC)

Department of Public Health, Aarhus University, Aarhus, Denmark.

Yvonne T van der Schouw (YT)

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Kim Overvad (K)

Department of Public Health, Aarhus University, Aarhus, Denmark.

Cecilie Kyrø (C)

Danish Cancer Society Research Center, Copenhagen, Denmark.

Anne Tjønneland (A)

Danish Cancer Society Research Center, Copenhagen, Denmark.

Rudolf Kaaks (R)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Verena Katzke (V)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Catarina Schiborn (C)

Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
German Center for Diabetes Research (DZD), Neuherberg, Germany.

Matthias B Schulze (MB)

Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Institute for Nutritional Science, University of Potsdam, Nuthetal, Germany.

Ana-Lucia Mayen-Chacon (AL)

Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), World Health Organization (WHO), Lyon, France.

Giovanna Masala (G)

Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.

Sabina Sieri (S)

Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori Di Milano, Milan, Italy.

Maria Santucci de Magistris (MS)

Azienda Ospedaliera Universitaria Federico II, Naples, Italy.

Rosario Tumino (R)

Hyblean Association for Epidemiological Research AIRE-ONLUS, Ragusa, Italy.

Carlotta Sacerdote (C)

Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy.

Jolanda M A Boer (JMA)

National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

W M Monique Verschuren (WMM)

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

Magritt Brustad (M)

Department of Community Medicine, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway.
The Public Dental Service Competence Centre of Northern Norway (TkNN), Tromsø, Norway.

Therese Haugdahl Nøst (TH)

Department of Community Medicine, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway.
K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.

Marta Crous-Bou (M)

Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO)-Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Dafina Petrova (D)

Escuela Andaluza de Salud Pública (EASP), Granada, Spain.
Instituto de Investigación Biosanitaria Ibs.GRANADA, Granada, Spain.
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, C. de Melchor Fernández Almagro, Madrid, Spain.

Pilar Amiano (P)

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, C. de Melchor Fernández Almagro, Madrid, Spain.
Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain.
Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain.

José María Huerta (JM)

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, C. de Melchor Fernández Almagro, Madrid, Spain.
Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.

Conchi Moreno-Iribas (C)

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, C. de Melchor Fernández Almagro, Madrid, Spain.
Navarra Institute for Health Research (IdiSNA), Pamplona, SpainInstituto de Salud Pu´Blica de Navarra, IdiSNA, Navarre Institute for Health Research, Pamplona, Spain.

Gunnar Engström (G)

Department of Clinical Science in Malmö, Lund University, Clinical Research Center, Malmö, Sweden.

Olle Melander (O)

Department of Clinical Science in Malmö, Lund University, Clinical Research Center, Malmö, Sweden.
Department of Emergency and Internal Medicine, Skåne University Hospital, Malmö, Sweden.

Kristina Johansson (K)

Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

Kristina Lindvall (K)

Department of Epidemiology and Global Health, Umeå University, Umeå, Sweden.

Elom K Aglago (EK)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.

Alicia K Heath (AK)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.

Adam S Butterworth (AS)

British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
British Heart Foundation Centre of Research Excellence, University of Cambridge, Hills Road, Cambridge, UK.
Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.

John Danesh (J)

British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
British Heart Foundation Centre of Research Excellence, University of Cambridge, Hills Road, Cambridge, UK.
Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK.

Timothy J Key (TJ)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK.

Classifications MeSH