Interleukin-6 and -27 as potential novel biomarkers for human pleural tuberculosis regardless of the immunological status.
Cytokine
HIV
Human
Pleural
Tuberculosis
Journal
Microbes and infection
ISSN: 1769-714X
Titre abrégé: Microbes Infect
Pays: France
ID NLM: 100883508
Informations de publication
Date de publication:
05 Oct 2023
05 Oct 2023
Historique:
received:
16
06
2023
revised:
02
10
2023
accepted:
03
10
2023
pubmed:
8
10
2023
medline:
8
10
2023
entrez:
7
10
2023
Statut:
aheadofprint
Résumé
Tuberculosis (TB) is the leading cause of pleural exudative effusions. Inflammatory markers, such as IFNγ and ADA, have been used as proxies for its diagnosis. We evaluated ex vivo levels of several cytokines in 83 pleural effusion specimens from patients with TB (including 10 with HIV co-infection) and 26 patients with other pleuritis using multiplex and ELISA assays. IL-6 and IL-27 levels were higher (p ≤ 0.04) in TB patients, regardless of the HIV status and the approach. IL-2, IL-4, IL-8, IFNγ, TNF and G-CSF showed variable results depending on the assay. This warranty these markers to be further validated.
Identifiants
pubmed: 37805123
pii: S1286-4579(23)00141-7
doi: 10.1016/j.micinf.2023.105238
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105238Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.