Strat-M® positioning for skin permeation studies: A comparative study including EpiSkin® RHE, and human skin.
Excised human skin
High-performance liquid chromatography
Human skin models
Lipid analysis
Permeation assays
Raman spectroscopy
Reconstructed human skin
Resorcinol
Strat-M®
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
25 Nov 2023
25 Nov 2023
Historique:
received:
04
07
2023
revised:
25
09
2023
accepted:
04
10
2023
medline:
27
11
2023
pubmed:
8
10
2023
entrez:
7
10
2023
Statut:
ppublish
Résumé
In the development and optimization of dermatological products, In Vitro Permeation Testing (IVPT) is pivotal for controlled study of skin penetration. To enhance standardization and replicate human skin properties reconstructed human skin and synthetic membranes are explored as alternatives. Strat-M® is a membrane designed to mimic the multi-layered structure of human skin for IVPT. For instance, in Strat-M®, the steady-state fluxes (J
Identifiants
pubmed: 37805151
pii: S0378-5173(23)00909-2
doi: 10.1016/j.ijpharm.2023.123488
pii:
doi:
Substances chimiques
Membranes, Artificial
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
123488Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.