Human-gut bacterial protein-protein interactions: understudied but impactful to human health.
disease
gut barrier
gut microbiome
immune system
protein–protein interaction
Journal
Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916
Informations de publication
Date de publication:
05 Oct 2023
05 Oct 2023
Historique:
received:
06
06
2023
revised:
12
09
2023
accepted:
14
09
2023
medline:
8
10
2023
pubmed:
8
10
2023
entrez:
7
10
2023
Statut:
aheadofprint
Résumé
The human gut microbiome is associated with a wide range of diseases; yet, the mechanisms these microbes use to influence human health are not fully understood. Protein-protein interactions (PPIs) are increasingly identified as a potential mechanism by which gut microbiota influence their human hosts. Similar to some PPIs observed in pathogens, many disease-relevant human-gut bacterial PPIs function by interacting with components of the immune system or the gut barrier. Here, we highlight recent advances in these two areas. It is our opinion that there is a vastly unexplored network of human-gut bacterial PPIs that contribute to the prevention or pathogenesis of various diseases and that future research is warranted to expand PPI discovery.
Identifiants
pubmed: 37805334
pii: S0966-842X(23)00271-8
doi: 10.1016/j.tim.2023.09.009
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIBIB NIH HHS
ID : T32 EB023860
Pays : United States
Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors have no interests to declare.