Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts.

Humans Air Pollutants / toxicity Air Pollution / adverse effects Cohort Studies Environmental Exposure / adverse effects Multiple Myeloma / chemically induced Nitrogen Dioxide / toxicity Particulate Matter / analysis
Air pollution Multiple myeloma Nitrogen dioxide Ozone Particulate matter

Journal

Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621

Informations de publication

Date de publication:
15 Dec 2023
Historique:
received: 03 07 2023
revised: 08 09 2023
accepted: 09 09 2023
medline: 27 11 2023
pubmed: 9 10 2023
entrez: 8 10 2023
Statut: ppublish

Résumé

Air pollution is a growing concern worldwide, with significant impacts on human health. Multiple myeloma is a type of blood cancer with increasing incidence. Studies have linked air pollution exposure to various types of cancer, including leukemia and lymphoma, however, the relationship with multiple myeloma incidence has not been extensively investigated. We pooled four European cohorts (N = 234,803) and assessed the association between residential exposure to nitrogen dioxide (NO During 4,415,817 person-years of follow-up (average 18.8 years), we observed 404 cases of multiple myeloma. The results of the fully adjusted linear analyses showed hazard ratios (95% confidence interval) of 0.99 (0.84, 1.16) per 10 μg/m³ NO We did not observe an association between long-term ambient air pollution exposure and incidence of multiple myeloma.

Sections du résumé

BACKGROUND BACKGROUND
Air pollution is a growing concern worldwide, with significant impacts on human health. Multiple myeloma is a type of blood cancer with increasing incidence. Studies have linked air pollution exposure to various types of cancer, including leukemia and lymphoma, however, the relationship with multiple myeloma incidence has not been extensively investigated.
METHODS METHODS
We pooled four European cohorts (N = 234,803) and assessed the association between residential exposure to nitrogen dioxide (NO
RESULTS RESULTS
During 4,415,817 person-years of follow-up (average 18.8 years), we observed 404 cases of multiple myeloma. The results of the fully adjusted linear analyses showed hazard ratios (95% confidence interval) of 0.99 (0.84, 1.16) per 10 μg/m³ NO
CONCLUSIONS CONCLUSIONS
We did not observe an association between long-term ambient air pollution exposure and incidence of multiple myeloma.

Identifiants

DOI: 10.1016/j.envres.2023.117230 PMID: 37806476
pubmed: 37806476
pii: S0013-9351(23)02034-0
doi: 10.1016/j.envres.2023.117230
pii:
doi:

Substances chimiques

Air Pollutants 0
Nitrogen Dioxide S7G510RUBH
Particulate Matter 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

117230

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Ulla Arthur Hvidtfeldt (UA)

The Danish Cancer Institute, Copenhagen, Denmark. Electronic address: ullah@cancer.dk.

Jie Chen (J)

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.

Sophia Rodopoulou (S)

Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Maciej Strak (M)

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; National Institute for Public Health and the Environment, Bilthoven, the Netherlands.

Kees de Hoogh (K)

Swiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland.

Zorana J Andersen (ZJ)

Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Tom Bellander (T)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Jørgen Brandt (J)

Department of Environmental Science, Aarhus University, Roskilde, Denmark; iClimate - interdisciplinary Centre for Climate Change, Aarhus University, Roskilde, Denmark.

Francesco Forastiere (F)

Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy; Environmental Research Group, School of Public Health, Faculty of Medicine, Imperial College, London, UK.

Boel Brynedal (B)

Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.

Ole Hertel (O)

Departments of Ecoscience, Aarhus University, Roskilde, Denmark.

Barbara Hoffmann (B)

Institute for Occupational, Social and Environmental Medicine, Centre for Health and Society, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Klea Katsouyanni (K)

Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.

Matthias Ketzel (M)

Department of Environmental Science, Aarhus University, Roskilde, Denmark; Global Centre for Clean Air Research (GCARE), University of Surrey, Guildford, GU2 7XH, United Kingdom.

Karin Leander (K)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Patrik K E Magnusson (PKE)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Gabriele Nagel (G)

Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.

Göran Pershagen (G)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Debora Rizzuto (D)

Department of Neurobiology, Care Sciences, And Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Stockholm Gerontology Research Center, Stockholm, Sweden.

Evangelia Samoli (E)

Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Rina So (R)

Department of Public Health, University of Copenhagen, Copenhagen, Denmark; Department of Epidemiology and Public Health, University College London, London, United Kingdom.

Massimo Stafoggia (M)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy.

Anne Tjønneland (A)

The Danish Cancer Institute, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Gudrun Weinmayr (G)

Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.

Kathrin Wolf (K)

Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.

Emanuel Zitt (E)

Agency for Preventive and Social Medicine (aks), Bregenz, Austria; Department of Internal Medicine 3, LKH Feldkirch, Feldkirch, Austria.

Bert Brunekreef (B)

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.

Gerard Hoek (G)

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.

Ole Raaschou-Nielsen (O)

The Danish Cancer Institute, Copenhagen, Denmark; Department of Environmental Science, Aarhus University, Roskilde, Denmark.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multiple myeloma risk in relation to long-term...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Polluants atmosphériques › Multiple myeloma risk in relation to long-term...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Pollution de l'air › Multiple myeloma risk in relation to long-term...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Multiple myeloma risk in relation to long-term...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Multiple myeloma risk in relation to long-term...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Paraprotéinémies › Myélome multiple › Multiple myeloma risk in relation to long-term...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Dioxyde d'azote › Multiple myeloma risk in relation to long-term...
questionsmedicales.fr › Mélanges complexes › Matière particulaire › Multiple myeloma risk in relation to long-term...