Antioxidative effects of ghrelin on human trabecular meshwork cells.
Antioxidation
Antioxydants
Cellules trabéculaires humaines
Ghrelin
Ghréline
Glaucome primaire à angle ouvert (GPAO)
Human trabecular meshwork cells
Oxidative stress
Primary open-angle glaucoma
Stress oxydant
Journal
Journal francais d'ophtalmologie
ISSN: 1773-0597
Titre abrégé: J Fr Ophtalmol
Pays: France
ID NLM: 7804128
Informations de publication
Date de publication:
06 Oct 2023
06 Oct 2023
Historique:
received:
03
09
2022
revised:
31
10
2022
accepted:
11
11
2022
medline:
9
10
2023
pubmed:
9
10
2023
entrez:
8
10
2023
Statut:
aheadofprint
Résumé
Glaucoma is a group of neurodegenerative diseases characterized by loss of retinal ganglion cells and visual field defects and is one of the major causes of irreversible blindness worldwide. Primary open-angle glaucoma (POAG) is one of the classifications of glaucoma. Oxidative stress in trabecular reticulated cells is one of the possible mechanisms of the development of glaucoma. At present, there is still a lack of effective methods to treat glaucoma. Ghrelin is characterized by its wide distribution and high potency and has anti-inflammatory, antioxidant, and anti-apoptotic effects, which may be beneficial in the treatment of glaucoma. In this study, we investigated whether ghrelin can protect human trabecular meshwork cells (HTMCs) from oxidative damage induced by hydrogen peroxide (H
Identifiants
pubmed: 37806937
pii: S0181-5512(23)00144-4
doi: 10.1016/j.jfo.2022.11.023
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023. Published by Elsevier Masson SAS.