Epileptic seizures at multiple sclerosis onset and their role in disease progression.
epidemiology
epilepsy
multiple sclerosis
Journal
Therapeutic advances in neurological disorders
ISSN: 1756-2856
Titre abrégé: Ther Adv Neurol Disord
Pays: England
ID NLM: 101480242
Informations de publication
Date de publication:
2023
2023
Historique:
received:
19
12
2022
accepted:
20
07
2023
medline:
9
10
2023
pubmed:
9
10
2023
entrez:
9
10
2023
Statut:
epublish
Résumé
Epileptic seizures can occur throughout the course of multiple sclerosis (MS) and are associated with increasing disability progression over time. However, there are no data on whether epileptic seizures at the onset of MS also lead to increasing disability. To examine disease progression over time for MS patients with epileptic seizures at onset. We analyzed the data of 30,713 patients on the German Multiple Sclerosis Register in a case-control study for more than 15 years. MS patients with seizures at onset were further divided into subgroups with polysymptomatic and monosymptomatic onset to assess the impact of additional symptoms on disease progression. A total of 46 patients had seizures as onset symptoms. Expanded Disability Status Scale (EDSS) within the first year was lower in the group with seizures at onset compared to controls (0.75 Epileptic seizures at MS onset are associated with a higher amount of disability progression over time. Additional longitudinal data are needed to further clarify the impact of seizures on the pathophysiology of MS disease progression.
Sections du résumé
Background
UNASSIGNED
Epileptic seizures can occur throughout the course of multiple sclerosis (MS) and are associated with increasing disability progression over time. However, there are no data on whether epileptic seizures at the onset of MS also lead to increasing disability.
Objective
UNASSIGNED
To examine disease progression over time for MS patients with epileptic seizures at onset.
Methods
UNASSIGNED
We analyzed the data of 30,713 patients on the German Multiple Sclerosis Register in a case-control study for more than 15 years. MS patients with seizures at onset were further divided into subgroups with polysymptomatic and monosymptomatic onset to assess the impact of additional symptoms on disease progression.
Results
UNASSIGNED
A total of 46 patients had seizures as onset symptoms. Expanded Disability Status Scale (EDSS) within the first year was lower in the group with seizures at onset compared to controls (0.75
Conclusion
UNASSIGNED
Epileptic seizures at MS onset are associated with a higher amount of disability progression over time. Additional longitudinal data are needed to further clarify the impact of seizures on the pathophysiology of MS disease progression.
Identifiants
pubmed: 37808247
doi: 10.1177/17562864231192826
pii: 10.1177_17562864231192826
pmc: PMC10559692
doi:
Types de publication
Journal Article
Langues
eng
Pagination
17562864231192826Informations de copyright
© The Author(s), 2023.
Références
Mult Scler. 2017 Mar;23(3):473-482
pubmed: 27260699
Mult Scler. 2022 May;28(6):942-949
pubmed: 34595974
Mult Scler. 2016 Feb;22(2):250-3
pubmed: 26084350
Eur J Neurol. 2022 Dec;29(12):3537-3546
pubmed: 36083790
J Neurol Neurosurg Psychiatry. 2012 Jan;83(1):49-54
pubmed: 21890577
Mult Scler. 2015 Mar;21(3):342-9
pubmed: 25533301
Neurol Sci. 2017 Mar;38(3):399-406
pubmed: 28054170
Seizure. 2017 Nov;52:131-135
pubmed: 29031194
Mult Scler. 2019 Oct;25(12):1641-1652
pubmed: 30230952
Sci Rep. 2021 Jun 25;11(1):13340
pubmed: 34172792
Nervenarzt. 2005 Aug;76(8):967-75
pubmed: 15806419
Mult Scler. 2011 Jan;17(1):96-102
pubmed: 20861180
Neurology. 2017 Dec 12;89(24):2462-2468
pubmed: 29117950
BMC Neurol. 2014 Mar 25;14:58
pubmed: 24666846
Mult Scler Relat Disord. 2020 Feb;38:101497
pubmed: 31726355
Brain. 2000 May;123 ( Pt 5):1027-40
pubmed: 10775547
Neuroscientist. 2012 Aug;18(4):360-72
pubmed: 22235060
Mult Scler Relat Disord. 2020 Nov;46:102485
pubmed: 32980646
J Neurol. 2021 May;268(5):1721-1727
pubmed: 33324995