Sex chromosome mechanisms in cardiac development and disease.
Journal
Nature cardiovascular research
ISSN: 2731-0590
Titre abrégé: Nat Cardiovasc Res
Pays: England
ID NLM: 9918284280206676
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
medline:
9
10
2023
pubmed:
9
10
2023
entrez:
9
10
2023
Statut:
ppublish
Résumé
Many human diseases, including cardiovascular disease, show differences between men and women in pathology and treatment outcomes. In the case of cardiac disease, sex differences are exemplified by differences in the frequency of specific types of congenital and adult-onset heart disease. Clinical studies have suggested that gonadal hormones are a factor in sex bias. However, recent research has shown that gene and protein networks under non-hormonal control also account for cardiac sex differences. In this review, we describe the sex chromosome pathways that lead to sex differences in the development and function of the heart and highlight how these findings affect future care and treatment of cardiac disease.
Identifiants
pubmed: 37808586
doi: 10.1038/s44161-023-00256-4
pmc: PMC10558115
mid: NIHMS1930004
doi:
Types de publication
Journal Article
Langues
eng
Pagination
340-350Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK083561
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD100298
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK083561
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL119886
Pays : United States
Déclaration de conflit d'intérêts
COMPETING INTERESTS The authors declare no competing interests.
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