The Impact of Intermittent Hypoxemia on Type 1 Retinopathy of Prematurity in Preterm Infants.
Journal
medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986
Informations de publication
Date de publication:
26 Sep 2023
26 Sep 2023
Historique:
medline:
9
10
2023
pubmed:
9
10
2023
entrez:
9
10
2023
Statut:
epublish
Résumé
Intermittent hypoxemia (IH) may influence retinopathy of prematurity (ROP) development in preterm infants, however, previous studies had mixed results. This study aims to assess the influence and evaluate the predictive ability of IH measures on Type 1 ROP, a stage beyond which ROP treatment is indicated. IH was quantified by continuously monitoring oxygen saturation (SpO Univariate analyses suggested that IH measures are greater in infants with Type 1 ROP and are predictive of Type 1 ROP development. Multivariable logistic regression analyses revealed that cumulative IH of longer duration during certain postnatal periods are associated with Type 1 ROP development after adjusting for gestational age (GA) or birth weight (BW). Although area under the curve (AUC) analyses revealed added predictivity of cumulative IH variables above GA or BW, these increments in AUC were not statistically significant. The duration of IH events was associated with Type 1 ROP development. Interventions for reducing the duration of IH events may potentially improve ROP outcomes.
Sections du résumé
Background
UNASSIGNED
Intermittent hypoxemia (IH) may influence retinopathy of prematurity (ROP) development in preterm infants, however, previous studies had mixed results. This study aims to assess the influence and evaluate the predictive ability of IH measures on Type 1 ROP, a stage beyond which ROP treatment is indicated.
Methods
UNASSIGNED
IH was quantified by continuously monitoring oxygen saturation (SpO
Results
UNASSIGNED
Univariate analyses suggested that IH measures are greater in infants with Type 1 ROP and are predictive of Type 1 ROP development. Multivariable logistic regression analyses revealed that cumulative IH of longer duration during certain postnatal periods are associated with Type 1 ROP development after adjusting for gestational age (GA) or birth weight (BW). Although area under the curve (AUC) analyses revealed added predictivity of cumulative IH variables above GA or BW, these increments in AUC were not statistically significant.
Conclusions
UNASSIGNED
The duration of IH events was associated with Type 1 ROP development. Interventions for reducing the duration of IH events may potentially improve ROP outcomes.
Identifiants
pubmed: 37808800
doi: 10.1101/2023.09.25.23295922
pmc: PMC10557831
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NINDS NIH HHS
ID : R21 NS114771
Pays : United States
Organisme : NINDS NIH HHS
ID : R41 NS122722
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB028792
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD091118
Pays : United States
Organisme : NINDS NIH HHS
ID : R56 NS117587
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD101508
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001998
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG062480
Pays : United States
Organisme : NICHD NIH HHS
ID : K23 HD109471
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest: The authors declare no conflict of interest. Competing Interests The authors declare no competing interest.