The Ethics of Human Brain Organoid Transplantation in Animals.
Brain organoids
Chimeras
Consciousness
Enhancement
Transplantation
Journal
Neuroethics
ISSN: 1874-5490
Titre abrégé: Neuroethics
Pays: Netherlands
ID NLM: 101468977
Informations de publication
Date de publication:
2023
2023
Historique:
received:
29
04
2023
accepted:
11
09
2023
medline:
9
10
2023
pubmed:
9
10
2023
entrez:
9
10
2023
Statut:
ppublish
Résumé
In this paper, we outline how one might conduct a comprehensive ethical evaluation of human brain organoid transplantation in animals. Thus far, ethical concerns regarding this type of research have been assumed to be similar to those associated with other transplants of human cells in animals, and have therefore not received significant attention. The focus has been only on the welfare, moral status, or mental capacities of the host animal. However, the transplantation of human brain organoids introduces several new ethical issues. Many of these are related to uncertainty regarding whether or not brain organoids might be conscious. While these concerns might not be immediately relevant, they warrant closer scrutiny. We discuss how various ethical issues are relevant to different stages of human brain organoid transplantation and can guide the ethical evaluation of research. Our examination would broaden the horizons of the debate on the transplantation of brain organoids.
Identifiants
pubmed: 37809032
doi: 10.1007/s12152-023-09532-3
pii: 9532
pmc: PMC10550858
doi:
Types de publication
Journal Article
Langues
eng
Pagination
27Informations de copyright
© The Author(s) 2023.
Déclaration de conflit d'intérêts
Competing InterestsJS is a Partner Investigator on an Australian Research Council grant LP190100841 which involves industry partnership from Illumina. He does not personally receive any funds from Illumina. JS is a Bioethics Committee consultant for Bayer. The other authors declare that there is no conflict of interest.
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