Immunophenotypic Characterization of Citrate-Containing A Concentrates in Maintenance Hemodialysis: A Pre-Post Study.
Journal
International journal of nephrology
ISSN: 2090-214X
Titre abrégé: Int J Nephrol
Pays: United States
ID NLM: 101546753
Informations de publication
Date de publication:
2023
2023
Historique:
received:
22
09
2022
revised:
07
06
2023
accepted:
21
06
2023
medline:
9
10
2023
pubmed:
9
10
2023
entrez:
9
10
2023
Statut:
epublish
Résumé
Due to chronic inflammation, maintenance hemodialysis (MHD) patients continue to show excess mortality. Acetate-free citrate-buffered A concentrates could be a way to improve the biocompatibility of the procedure, reduce chronic inflammation, and thus in the long term improve the prognosis of patients. Using a pre-post design (3 months of acetate followed by 3 months of citrate-acidified A concentrates in standard bicarbonate-based dialysate hemodialysis, CiaHD) and linear mixed model analysis in 61 stable HD patients, we assessed the impact of CiaHD on counts and phenotypes of peripheral T cells and monocytes by flow cytometry. Switching to CiaHD left C-reactive protein (CRP) levels and leucocyte counts unaffected. However, CiaHD increased lymphocyte counts ex vivo. Furthermore, we found a decrease in total CD3+CD4+CD69+ ((10 Compared with acetate, CiaHD has a minor impact on lymphocyte counts and CD4+T-cell activation, which was independent of systemic CRP and ionized magnesium, calcium levels, and other dialysis prescription modalities.
Identifiants
pubmed: 37809041
doi: 10.1155/2023/7772677
pmc: PMC10551471
doi:
Types de publication
Journal Article
Langues
eng
Pagination
7772677Informations de copyright
Copyright © 2023 Yuli Shen et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
Références
CEN Case Rep. 2020 Aug;9(3):243-246
pubmed: 32221815
Hum Immunol. 2019 Sep;80(9):748-754
pubmed: 30853362
Sci Rep. 2017 Oct 17;7(1):13368
pubmed: 29042624
Kidney Int. 2001 Apr;59(4):1382-9
pubmed: 11260399
Am J Kidney Dis. 2019 Mar;73(3):432-434
pubmed: 30502221
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14733-8
pubmed: 20679213
Ther Apher Dial. 2011 Oct;15(5):460-5
pubmed: 21974699
Nephrol Dial Transplant. 2017 Apr 1;32(4):707-714
pubmed: 28407129
N Engl J Med. 1977 Apr 7;296(14):769-74
pubmed: 840277
Scand J Immunol. 2015 Aug;82(2):135-41
pubmed: 25969863
Kidney Int. 2010 Jan;77(2):141-51
pubmed: 19907414
Blood Purif. 2021;50(6):914-920
pubmed: 33535212
Kidney Int. 2006 Jul;70(2):371-6
pubmed: 16738532
Clin J Am Soc Nephrol. 2010 Feb;5(2):227-34
pubmed: 20056757
Toxins (Basel). 2020 Jul 05;12(7):
pubmed: 32635646
Mediators Inflamm. 2017;2017:1070959
pubmed: 29200664
Am J Kidney Dis. 2020 Jan;75(1 Suppl 1):A6-A7
pubmed: 31704083
J Am Soc Nephrol. 2004 Nov;15(11):2916-22
pubmed: 15504945
Viral Immunol. 2017 Mar;30(2):82-97
pubmed: 28051364
J Exp Med. 2000 Oct 2;192(7):1027-34
pubmed: 11015443
J Am Soc Nephrol. 2002 Jan;13(1):204-212
pubmed: 11752039
Blood Purif. 2012;34(3-4):354-63
pubmed: 23406818
Kidney Int. 2002 Nov;62(5):1791-8
pubmed: 12371981
BMC Nephrol. 2013 Oct 09;14:216
pubmed: 24103587
Blood Purif. 2006;24(5-6):508-16
pubmed: 17077623
Kidney Int. 1999 Mar;55(3):1081-90
pubmed: 10027947
Nephrol Dial Transplant. 2018 Nov 1;33(11):2043-2051
pubmed: 29860419
Nature. 2011 Jul 27;475(7357):471-6
pubmed: 21796205
Inflammation. 2016 Feb;39(1):79-86
pubmed: 26253296
Nature. 2011 Jul 27;475(7357):462-3
pubmed: 21796201
Toxins (Basel). 2021 Jan 19;13(1):
pubmed: 33477769
Front Immunol. 2020 Sep 29;11:583702
pubmed: 33117396
Cell Rep. 2019 May 14;27(7):2063-2074.e5
pubmed: 31091446
Nat Commun. 2016 Jul 06;7:12150
pubmed: 27381735
Kidney Int. 2017 May;91(5):1236-1242
pubmed: 28215666
J Am Soc Nephrol. 2017 Jan;28(1):359-367
pubmed: 27413076
Semin Dial. 2010 Sep-Oct;23(5):498-509
pubmed: 21039875
Sci Rep. 2019 Jul 23;9(1):10622
pubmed: 31337804
Front Immunol. 2021 Mar 17;12:644627
pubmed: 33815398
Immunol Rev. 2013 Sep;255(1):210-21
pubmed: 23947357
BMC Nephrol. 2020 Jul 13;21(1):271
pubmed: 32660510
Ren Fail. 2017 Nov;39(1):547-554
pubmed: 28726529