Mathematical modeling of active contraction of the human cardiac myocyte: A review.
Active contraction
Cardiac muscle
Heart
Mathematical modeling
Mathematical physiology
Myocyte
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
06
06
2023
revised:
26
08
2023
accepted:
10
09
2023
medline:
9
10
2023
pubmed:
9
10
2023
entrez:
9
10
2023
Statut:
epublish
Résumé
In this present research paper, a mathematical model has been developed to study myocyte contraction in the human cardiac muscle, using the Land model. Different parts of the human heart with a focus on the composition of the myocyte cells have been explored numerically to enabling us to determine the interaction of various parameters in the heart muscle. The main objective of the work is to direct the study of the Land model, which has been exploited to simulate the contraction of real human myocytes. Mathematical models has been developed based on the Hill model and Huxley model. Myocyte contraction for different scenarios, such as in isometric tension and isotonic tension have been studied. It is found that increase in stretch, the peak active tension increases, in line with well-established length-dependent tension generation. Five parameters are selected: [Ca In conclusion, it is found that the Land model provides a good platform for the analysis of the active contraction of the human cardiac myocyte.
Sections du résumé
Background and objective
UNASSIGNED
In this present research paper, a mathematical model has been developed to study myocyte contraction in the human cardiac muscle, using the Land model. Different parts of the human heart with a focus on the composition of the myocyte cells have been explored numerically to enabling us to determine the interaction of various parameters in the heart muscle. The main objective of the work is to direct the study of the Land model, which has been exploited to simulate the contraction of real human myocytes.
Methods
UNASSIGNED
Mathematical models has been developed based on the Hill model and Huxley model. Myocyte contraction for different scenarios, such as in isometric tension and isotonic tension have been studied.
Results
UNASSIGNED
It is found that increase in stretch, the peak active tension increases, in line with well-established length-dependent tension generation. Five parameters are selected: [Ca
Conclusion
UNASSIGNED
In conclusion, it is found that the Land model provides a good platform for the analysis of the active contraction of the human cardiac myocyte.
Identifiants
pubmed: 37809539
doi: 10.1016/j.heliyon.2023.e20065
pii: S2405-8440(23)07273-0
pmc: PMC10559823
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e20065Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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