Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling.
Fibrosis
Gene network
Model organism
Molecular interaction
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
20 Oct 2023
20 Oct 2023
Historique:
received:
19
04
2023
revised:
02
08
2023
accepted:
13
09
2023
medline:
9
10
2023
pubmed:
9
10
2023
entrez:
9
10
2023
Statut:
epublish
Résumé
Minichromosome maintenance 6 (MCM6) has been implicated in the progression of various malignant tumors; however, its exact physiological function in kidney diseases remains unclear. Here, we demonstrated that MCM6 levels showed a significant increase in the proximal tubular cells during progressive renal fibrosis in two unrelated
Identifiants
pubmed: 37810227
doi: 10.1016/j.isci.2023.107940
pii: S2589-0042(23)02017-5
pmc: PMC10558752
doi:
Types de publication
Journal Article
Langues
eng
Pagination
107940Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
All authors declare that they have no conflict of interest.
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