Prelimbic area to lateral hypothalamus circuit drives social aggression.
Behavioral neuroscience
Cellular neuroscience
Molecular neuroscience
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
20 Oct 2023
20 Oct 2023
Historique:
received:
12
01
2023
revised:
06
06
2023
accepted:
22
08
2023
medline:
9
10
2023
pubmed:
9
10
2023
entrez:
9
10
2023
Statut:
epublish
Résumé
Controlling aggression is a vital skill in social species such as rodents and humans and has been associated with the medial prefrontal cortex (mPFC). In this study, we showed that during aggressive behavior, the activity of GABAergic neurons in the prelimbic area (PL) of the mPFC was significantly suppressed. Specific activation of GABAergic PL neurons significantly curbed male-to-male aggression and inhibited conditioned place preference (CPP) for aggression-paired contexts, whereas specific inhibition of GABAergic PL neurons brought about the opposite effect. Moreover, GABAergic projections from PL neurons to the lateral hypothalamus (LH) orexinergic neurons mediated aggressive behavior. Finally, directly modulated LH-orexinergic neurons influence aggressive behavior. These results suggest that GABAergic PL-orexinergic LH projection is an important control circuit for intermale aggressive behavior, both of which could be targets for curbing aggression.
Identifiants
pubmed: 37810230
doi: 10.1016/j.isci.2023.107718
pii: S2589-0042(23)01795-9
pmc: PMC10551839
doi:
Types de publication
Journal Article
Langues
eng
Pagination
107718Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Nature. 2005 Sep 22;437(7058):556-9
pubmed: 16100511
Physiol Behav. 2006 Jun 15;88(1-2):173-82
pubmed: 16687160
Nature. 2013 Jun 20;498(7454):363-6
pubmed: 23708967
Nature. 2018 Mar 22;555(7697):524-528
pubmed: 29539641
Sleep. 2012 Dec 01;35(12):1625-35
pubmed: 23204605
Science. 2001 Aug 10;293(5532):1159-63
pubmed: 11498596
J Neurosci. 1998 Dec 1;18(23):9996-10015
pubmed: 9822755
Nat Commun. 2016 Jul 22;7:12199
pubmed: 27448020
Hippocampus. 1996;6(4):347-470
pubmed: 8915675
Neuron. 2019 Jun 5;102(5):1053-1065.e4
pubmed: 31006556
Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8733-8
pubmed: 8710940
Cell Rep. 2022 Dec 13;41(11):111794
pubmed: 36516745
Nature. 2005 Oct 27;437(7063):1257-63
pubmed: 16251950
Cell Rep. 2020 Jun 23;31(12):107790
pubmed: 32579920
Nat Rev Neurosci. 2006 Apr;7(4):268-77
pubmed: 16552413
Nat Neurosci. 2020 May;23(5):638-650
pubmed: 32284606
Science. 2011 Nov 4;334(6056):697-700
pubmed: 22053054
Cereb Cortex. 2018 Jun 1;28(6):1980-1990
pubmed: 28498919
J Comp Neurol. 2010 Feb 1;518(3):389-404
pubmed: 19950390
Psychopharmacology (Berl). 2011 May;215(1):191-203
pubmed: 21181123
Neuron. 2018 Feb 21;97(4):911-924.e5
pubmed: 29398361
PLoS One. 2014 Apr 16;9(4):e94657
pubmed: 24740241
Mol Psychiatry. 2019 Sep;24(9):1351-1368
pubmed: 30755721
Eur Neuropsychopharmacol. 2020 Jan;30:5-16
pubmed: 29274996
Nat Rev Neurosci. 2013 Nov;14(11):786-99
pubmed: 24105343
Dev Neurobiol. 2011 Jan 1;71(1):45-61
pubmed: 21154909
Synapse. 2004 Jan;51(1):32-58
pubmed: 14579424
Science. 2017 Jul 14;357(6347):162-168
pubmed: 28706064
Science. 2018 Oct 26;362(6413):429-434
pubmed: 30361367
Addict Biol. 2018 Jan;23(1):247-255
pubmed: 28419646
J Comp Neurol. 2011 Dec 15;519(18):3766-801
pubmed: 21800317
Nat Neurosci. 2018 May;21(5):717-724
pubmed: 29632359
Curr Top Behav Neurosci. 2014;17:3-44
pubmed: 24318936
Nat Rev Neurosci. 2007 Jul;8(7):536-46
pubmed: 17585306
Front Syst Neurosci. 2016 Nov 14;10:92
pubmed: 27895561
Nat Neurosci. 1999 Nov;2(11):1032-7
pubmed: 10526345
J Comp Neurol. 2005 Nov 14;492(2):145-77
pubmed: 16196030
J Vis Exp. 2013 Jul 04;(77):e4367
pubmed: 23852258
Nat Neurosci. 2017 Feb;20(2):260-270
pubmed: 28067904
J Neurosci. 2014 Aug 27;34(35):11519-25
pubmed: 25164650
Cell Mol Neurobiol. 2018 Mar;38(2):385-391
pubmed: 28349223
Nature. 2022 Mar;603(7902):667-671
pubmed: 35296862
Neuron. 2015 Jul 15;87(2):437-50
pubmed: 26143660
Nat Neurosci. 2016 Dec;19(12):1743-1749
pubmed: 27798629
Science. 2011 Nov 4;334(6056):693-7
pubmed: 21960531
Nature. 2003 Nov 27;426(6965):442-6
pubmed: 14647382
Am J Psychiatry. 2008 Apr;165(4):429-42
pubmed: 18346997
Science. 2008 Jul 4;321(5885):53-7
pubmed: 18599766
Behav Brain Res. 2006 Nov 25;175(1):166-75
pubmed: 16978716
J Neurosci. 2012 May 30;32(22):7662-71
pubmed: 22649245
Nature. 2016 Jun 29;534(7609):688-92
pubmed: 27357796
Science. 1994 May 20;264(5162):1102-5
pubmed: 8178168
J Neurosci. 2012 Mar 28;32(13):4623-31
pubmed: 22457508
Nat Rev Neurosci. 2001 Jan;2(1):11-23
pubmed: 11253355
Biol Psychiatry. 1997 Sep 15;42(6):495-508
pubmed: 9285085
Neuron. 2009 Apr 30;62(2):171-89
pubmed: 19409263
Nature. 2013 Nov 28;503(7477):521-4
pubmed: 24097352
Neuron. 2016 Jun 15;90(6):1286-1298
pubmed: 27238864
Neuron. 2016 Jul 20;91(2):260-92
pubmed: 27477017
Nat Neurosci. 2016 Apr;19(4):596-604
pubmed: 26950005