Foregoing elective neck dissection for elderly patients with oral cavity squamous cell carcinoma.

aged carcinoma elective neck dissection humans mouth neoplasms old age retrospective squamous cell squamous cell carcinoma of head and neck survival rate

Journal

ANZ journal of surgery
ISSN: 1445-2197
Titre abrégé: ANZ J Surg
Pays: Australia
ID NLM: 101086634

Informations de publication

Date de publication:
09 Oct 2023
Historique:
revised: 29 08 2023
received: 01 04 2023
accepted: 16 09 2023
medline: 9 10 2023
pubmed: 9 10 2023
entrez: 9 10 2023
Statut: aheadofprint

Résumé

Elective neck dissection (END) improves outcomes among clinically node-negative patients with oral cavity squamous cell carcinoma (OCSCC). However, END is of questionable value, considering the potentially higher comorbidities and operative risks in elderly patients. A retrospective review of all patients older than 65 years of age who were treated for OCSCC at a tertiary care centre between 2005 and 2020 was conducted. Fifty-three patients underwent primary tumour resection alone, and 71 had simultaneous END. Most primary tumours were located on the mobile tongue. The patients who did not undergo END had a higher mean age (81.2 vs. 75.1 years, P < 0.00001), significantly shorter surgeries, and shorter hospitalizations. Occult cervical metastases were found in 24% of the patients who underwent END. The two groups showed no significant differences in overall survival or recurrence rates. Similar results were shown in a subpopulation analysis of patients older than 75 years. Foregoing END in elderly patients with no clinical evidence of neck metastases did not result in lower survival rates or higher recurrence rates.

Identifiants

pubmed: 37811844
doi: 10.1111/ans.18711
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023 Royal Australasian College of Surgeons.

Références

Cohen N, Fedewa S, Chen AY. Epidemiology and demographics of the head and neck cancer population. Oral Maxillofac. Surg. Clin. North Am. 2018; 30: 381-395.
Rettig EM, Souza D. Epidemiology of head and neck cancer. Surg. Oncol. Clin. N. Am. 2015; 24: 379-396.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018; 68: 394-424.
Choi S, Myers JN. Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy. J. Dent. Res. 2008; 87: 14-32.
Petersen PE. Oral cancer prevention and control-the approach of the World Health Organization q. Oral Oncol. 2009; 45: 454-460.
Braakhuis BJM, Leemans CR, Visser O. Incidence and survival trends of head and neck squamous cell carcinoma in The Netherlands between 1989 and 2011. Oral Oncol. 2014; 50: 670-675.
Gupta N, Gupta R, Acharya AK et al. Changing trends in oral cancer - a global scenario. Nepal J Epidemiol. 2017; 6: 613-619.
Tota JE, Anderson WF, Coffey C et al. Rising incidence of oral tongue cancer among white men and women in the United States, 1973-2012. Oral Oncol. 2017; 67: 146-152.
Myers JN, Elkins T, Roberts D, Byers RM. In young adults, squamous cell carcinoma of the tongue: increasing incidence and factors that predict treatment outcomes. Otolaryngol. Head Neck Surg. 2000; 122: 44-51.
Ng JH, Iyer NG, Tan MH, Edgren G. Changing epidemiology of oral squamous cell carcinoma of the tongue: a global study. Head Neck 2017; 39: 297-304.
Cervenka BP, Rao S, Bewley AF. Head and neck cancer and the elderly patient. Otolaryngol. Clin. N. Am. 2018; 51: 741-751.
Zhan KY, Morgan PF, Neskey DM et al. Preoperative predictors of occult nodal disease in cT1N0 oral cavity squamous cell carcinoma: review of 2623 cases. Head Neck 2018; 40: 1967-1976.
Arain AA, Rajput MSA, Ansari SA et al. Occult nodal metastasis in Oral cavity cancers. Cureus. 2020; 12: e11640.
D'Cruz AK, Vaish R, Kapre N et al. Elective versus therapeutic neck dissection in node-negative oral cancer. N. Engl. J. Med. 2015; 373: 521-529.
Nguyen E, McKenzie J, Clarke R, Lou S, Singh T. The indications for elective neck dissection in T1N0M0 oral cavity squamous cell carcinoma. J. Oral Maxillofac. Surg. 2021; 79: 1779-1793.
Ibrahim SA, Ahmed ANA, Elsersy HA, Darahem IMH. Elective neck dissection in T1/T2 oral squamous cell carcinoma with N0 neck: essential or not? A systematic review and meta-analysis. Eur. Arch. Otorhinolaryngol. 2020; 277: 1741-1752.
Hartmann S, Grandis JR. Treatment of head and neck cancer in the elderly. Expert. Opin. Pharmacother. 2016; 17: 1903-1921.
Harries M, Lund VJ. Head and neck surgery in the elderly: a maturing problem. J. Laryngol. Otol. 1989; 103: 306-309.
Liu WC, Liu HE, Kao YW et al. Definitive radiotherapy or surgery for early oral squamous cell carcinoma in old and very old patients: a propensity-score-matched, nationwide, population-based cohort study. Radiother. Oncol. 2020; 151: 214-221.
Govers TM, Schreuder WH, Klop WMC et al. Quality of life after different procedures for regional control in oral cancer patients: cross-sectional survey. Clin. Otolaryngol. 2016; 41: 228-233.
Lenze NR, Farquhar DR, Dorismond C et al. Age and risk of recurrence in oral tongue squamous cell carcinoma: systematic review. Head Neck 2020; 42: 3755-3768.
Du E, Mazul AL, Farquhar D et al. Long-term survival in head and neck cancer: impact of site, stage, smoking, and human papillomavirus status. Laryngoscope 2019; 129: 2506-2513.
Unger JM, Cook E, Tai E, Bleyer A. The role of clinical trial participation in cancer research: barriers, evidence, and strategies. Am. Soc. Clin. Oncol. Educ. Book 2016; 35: 185-198.
National Comprehensive Cancer Network. (2022). Head and Neck Cancers (version 2.2022). https://www.nccn.org/professionals/physician_gls/pdf/head-and-neck.pdf.
Nakamura E, Miyao K. A method for identifying biomarkers of aging and constructing an index of biological age in humans. J. Gerontol. A Biol. Sci. Med. Sci. 2007; 62: 1096-1105.
Nakamura E, Miyao K. Sex differences in human biological aging. J. Gerontol. A Biol. Sci. Med. Sci. 2008; 63: 936-944.
Chakrabarti D, Akhtar N, Qayoom S et al. Optimising elective neck dissection for early oral cancers. Oral Oncol. 2021; 114: 105090.
Feng Z, Cheng A, Alzahrani S, Li B, Han Z, Ward BB. Elective neck dissection in T1N0M0 oral squamous cell carcinoma: when is it necessary? J. Oral Maxillofac. Surg. 2020; 78: 2306-2315.
Shah JP. Patterns of cervical lymph node metastasis from squamous carcinomas of the upper aerodigestive tract. Am. J. Surg. 1990; 160: 405-409.
Cao Y, Wang T, Yu C, Guo X, Li C, Li L. Elective neck dissection versus wait-and-watch policy for oral cavity squamous cell carcinoma in early stage: a systematic review and meta-analysis based on survival data. J. Oral Maxillofac. Surg. 2019; 77: 2154-2167.
Fasunla AJ, Greene BH, Timmesfeld N, Wiegand S, Werner JA, Sesterhenn AM. A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck. Oral Oncol. 2011; 47: 320-324.
Koyama LKS, Matos LL, Kulcsar MAV, De Araújo Filho VJF, Cernea CR. Oral cancer treatment: still an indication for elective neck dissection? ORL J. Otorhinolaryngol Relat. Spec. 2018; 80: 96-102.
Basheeth N, O'Leary G, Sheahan P. Elective neck dissection for N0 neck during salvage total laryngectomy: findings, complications, and oncological outcome. JAMA Otolaryngol. Head Neck Surg. 2013; 139: 790-796.
Hernando J, Villarreal P, Álvarez-Marcos F, Gallego L, García-Consuegra L, Junquera L. Comparison of related complications: sentinel node biopsy versus elective neck dissection. Int. J. Oral Maxillofac. Surg. 2014; 43: 1307-1312.
Lin C, Puram SV, Bulbul MG et al. Elective neck dissection for salvage laryngectomy: a systematic review and meta-analysis. Oral Oncol. 2019; 96: 97-104.
de Bree R, Takes RP, Shah JP et al. Elective neck dissection in oral squamous cell carcinoma: past, present and future. Oral Oncol. 2019; 90: 87-93.
Jariod-Ferrer ÚM, Arbones-Mainar JM, Gavin-Clavero MA et al. Are comorbidities associated with overall survival in patients with oral squamous cell carcinoma? J. Oral Maxillofac. Surg. 2019; 77: 1906-1914.
Howard A, Agrawal N, Gooi Z. Lip and oral cavity squamous cell carcinoma. Hematol. Oncol. Clin. North Am. 2021; 35: 895-911.
Foster CC, Melotek JM, Brisson RJ et al. Definitive chemoradiation for locally-advanced oral cavity cancer: a 20-year experience. Oral Oncol. 2018; 80: 16-22.
Weinreb A. Why Is Israel's Life Expectancy So High?
Hilly O, Shkedy Y, Hod R et al. Carcinoma of the oral tongue in patients younger than 30 years: comparison with patients older than 60 years. Oral Oncol. 2013; 49: 987-990.
Lee DS, Ramirez RJ, Lee JJ et al. Survival of young versus old patients with oral cavity squamous cell carcinoma: a meta-analysis. Laryngoscope 2021; 131: 1310-1319.
Jia L, Zhang W, Chen X. Common methods of biological age estimation. Clin. Interv. Aging 2017; 12: 759-772.
Park J, Cho B, Kwon H, Lee C. Developing a biological age assessment equation using principal component analysis and clinical biomarkers of aging in Korean men. Arch. Gerontol. Geriatr. 2009; 49: 7-12.
Joseph B, Pandit V, Sadoun M et al. Frailty in surgery. J. Trauma Acute Care Surg. 2014; 76: 1151-1156.
Azam F, Latif MF, Farooq A et al. Performance status assessment by using ECOG (Eastern Cooperative Oncology Group) score for cancer patients by oncology healthcare professionals. Case Rep Oncol 2019; 12: 728-736.
Oliva EN, Nobile F, Alimena G et al. Quality of life in elderly patients with acute myeloid leukemia: patients may be more accurate than physicians. Haematologica 2011; 96: 696-702.
Krug U, Röllig C, Koschmieder A et al. Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomes. Lancet 2010; 376: 2000-2008.
Abu-Ghanem S, Yehuda M, Carmel NN et al. Elective neck dissection vs observation in early-stage squamous cell carcinoma of the oral tongue with no clinically apparent lymph node metastasis in the neck a systematic review and meta-analysis. JAMA Otolaryngol. Head Neck Surg. 2016; 142: 857-865.
Shia BC, Qin L, Lin KC et al. Outcomes for elderly patients aged 70 to 80 years or older with locally advanced oral cavity squamous cell carcinoma: a propensity score-matched, nationwide, oldest old patient-based cohort study. Cancers (Basel). 2020; 12: 258.
Ren ZH, Xu JL, Li B, Fan TF, Ji T, Zhang CP. Elective versus therapeutic neck dissection in node-negative oral cancer: evidence from five randomized controlled trials. Oral Oncol. 2015; 51: 976-981.
Ding Z, Li Y, Pan X, Xuan M, Xie H, Wang X. Sentinel lymph node biopsy versus elective neck dissection in squamous cell carcinoma of the oral cavity with a clinically N0 neck: systematic review and meta-analysis of prospective studies. Head Neck 2021; 43: 3185-3198.
Hasegawa Y, Tsukahara K, Yoshimoto S et al. Neck dissections based on sentinel lymph node navigation versus elective neck dissections in early Oral cancers: a randomized, multicenter, and noninferiority trial. J. Clin. Oncol. 2021; 39: 2025-2036.
Andersen PE, Cambronero E, Shaha AR, Shah JP. The extent of neck disease after regional failure during observation of the N0 neck. Am. J. Surg. 1996; 172: 689-691.

Auteurs

Nir Tsur (N)

Department of Otorhinolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah-Tikva, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Eyal Yosefof (E)

Department of Otorhinolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah-Tikva, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Dean Dudkiewicz (D)

Department of Otorhinolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah-Tikva, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Nofar Edri (N)

Department of Otorhinolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah-Tikva, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Sagit Stern (S)

Hadassah University Hospital, Otolaryngology / Head & Neck Surgery, Jerusalem, Israel.

Thomas Shpitzer (T)

Department of Otorhinolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah-Tikva, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Aviram Mizrachi (A)

Department of Otorhinolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah-Tikva, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Esmat Najjar (E)

Department of Otorhinolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah-Tikva, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Classifications MeSH