Adenylate kinase 9 is essential for sperm function and male fertility in mammals.
bovine
mutation
sperm
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
17 10 2023
17 10 2023
Historique:
pmc-release:
09
04
2024
medline:
1
11
2023
pubmed:
9
10
2023
entrez:
9
10
2023
Statut:
ppublish
Résumé
Despite passing routine laboratory tests for semen quality, bulls used in artificial insemination exhibit significant variation in fertility. Routine analysis of fertility data identified a dairy bull with extreme subfertility (10% pregnancy rate). To characterize the subfertility phenotype, a range of in vitro, in vivo, and molecular assays were carried out. Sperm from the subfertile bull exhibited reduced motility and severely reduced caffeine-induced hyperactivation compared to controls. Ability to penetrate the zona pellucida, cleavage rate, cleavage kinetics, and blastocyst yield after IVF or AI were significantly lower than in control bulls. Whole-genome sequencing from semen and RNA sequencing of testis tissue revealed a critical mutation in adenylate kinase 9 (
Identifiants
pubmed: 37812723
doi: 10.1073/pnas.2305712120
pmc: PMC10589668
doi:
Substances chimiques
Adenylate Kinase
EC 2.7.4.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2305712120Subventions
Organisme : Science Foundation Ireland
ID : 16/IA/4474
Pays : Ireland
Organisme : Swiss National Science Foundation
ID : 310030 185229
Pays : Switzerland
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