Comparative metabolomics study on areca nut from China and Southeast Asia (Thailand and Indonesia).
UHPLC-QQQ-MS
areca nut
medicinal value
metabolomics
production area
Journal
Phytochemical analysis : PCA
ISSN: 1099-1565
Titre abrégé: Phytochem Anal
Pays: England
ID NLM: 9200492
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
02
09
2023
received:
02
06
2023
accepted:
21
09
2023
medline:
4
12
2023
pubmed:
10
10
2023
entrez:
9
10
2023
Statut:
ppublish
Résumé
Areca nut is an economic crop and an important component in traditional Chinese medicine (TCM) and ethnomedicine. The crop is rich in alkaloids and flavonoids. Most previous studies have focused on the chemical components, especially alkaloids, in crops from certain areca nut-producing areas. The purpose of this study was to compare the differences in areca nut seeds in two main cultivation areas, identify differential metabolites, and evaluate seed quality in different production areas. A widely targeted metabolomics method based on ultrahigh-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC-QQQ-MS), combined with the TCM systems pharmacology (TCMSP) database and multivariate statistical analysis, was used in this study to maximise the differentiation between quality characteristics of areca nut seeds from China and Southeast Asian regions. Altogether, 1031 metabolites were identified in areca nut seeds; by querying the TCMSP database, 375 metabolites were identified as the main active ingredients. Moreover, the research showed that the metabolic profiles of areca nut seeds from China (ASCN) and Southeast Asia (ASSA) exhibit significant differences, and the difference is mainly reflected in 318 compounds. The relative content of 146 metabolites in ASCN was significantly higher than that in ASSA. Through Kyoto Encyclopedia of Genes and Genomes (KEGG) comparative analysis, areca nut seed metabolites in Chinese production areas were determined to have a wider metabolic pathway. The areca nut seeds from cultivation areas possess many metabolites that are beneficial for health, including alkaloids, amino acids, phenolic acids, and lipids. Thus, compared with ASSA, ASCN have a higher medicinal value. This study provides a direction for the subsequent development and utilisation of areca nut seeds.
Substances chimiques
Alkaloids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1022-1035Subventions
Organisme : Project of Medical and Health Science and Technology Innovation Engineering of the Chinese Academy of Medical Sciences
ID : 2021-1-I2M-032
Organisme : Major Science and Technology Project of Hainan Province, China
ID : ZDKJ2021034
Organisme : Major Science and Technology Project of Hainan Province, China
ID : ZDYF2021SHFZ047
Organisme : Major Science and Technology Project of Hainan Province, China
ID : ZDYF2022XDNY162
Organisme : Major Science and Technology Project of Wanning County
ID : 2022wnkj09
Informations de copyright
© 2023 John Wiley & Sons Ltd.
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