Identification of side effects of COVID-19 drug candidates on embryogenesis using an integrated zebrafish screening platform.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 10 2023
09 10 2023
Historique:
received:
27
06
2023
accepted:
29
09
2023
medline:
11
10
2023
pubmed:
10
10
2023
entrez:
9
10
2023
Statut:
epublish
Résumé
Drug repurposing is an important strategy in COVID-19 treatment, but many clinically approved compounds have not been extensively studied in the context of embryogenesis, thus limiting their administration during pregnancy. Here we used the zebrafish embryo model organism to test the effects of 162 marketed drugs on cardiovascular development. Among the compounds used in the clinic for COVD-19 treatment, we found that Remdesivir led to reduced body size and heart functionality at clinically relevant doses. Ritonavir and Baricitinib showed reduced heart functionality and Molnupiravir and Baricitinib showed effects on embryo activity. Sabizabulin was highly toxic at concentrations only 5 times higher than C
Identifiants
pubmed: 37813860
doi: 10.1038/s41598-023-43911-3
pii: 10.1038/s41598-023-43911-3
pmc: PMC10562458
doi:
Substances chimiques
baricitinib
ISP4442I3Y
spike protein, SARS-CoV-2
0
molnupiravir
YA84KI1VEW
Ritonavir
O3J8G9O825
Antiviral Agents
0
Pharmaceutical Preparations
0
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17037Informations de copyright
© 2023. Springer Nature Limited.
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