No evidence of an association of multiple sclerosis (MS) with Borna disease virus 1 (BoDV-1) infections in patients within an endemic region: a retrospective pilot study.
Borna disease virus (BoDV-1)
ELISA
Encephalitis
Multiple sclerosis (MS)
Serology
iIFA
Journal
Infection
ISSN: 1439-0973
Titre abrégé: Infection
Pays: Germany
ID NLM: 0365307
Informations de publication
Date de publication:
09 Oct 2023
09 Oct 2023
Historique:
received:
02
08
2023
accepted:
12
09
2023
medline:
10
10
2023
pubmed:
10
10
2023
entrez:
9
10
2023
Statut:
aheadofprint
Résumé
Borna disease virus 1 (BoDV-1) causes rare human infections within endemic regions in southern and eastern Germany. The infections reported to date have been linked to severe courses of encephalitis with high mortality and mostly irreversible symptoms. Whether BoDV-1 could act as a trigger for other neurological conditions, is, however, incompletely understood. In this study, we addressed the question of whether the presentation of a clinically isolated syndrome (CIS) or of multiple sclerosis (MS) might be associated with a milder course of BoDV-1 infections. Serum samples of 100 patients with CIS or MS diagnosed at a tertiary neurological care center within an endemic region in southern Germany and of 50 control patients suffering from headache were retrospectively tested for BoDV-1 infections. In none of the tested sera, confirmed positive results of anti-BoDV-1-IgG antibodies were retrieved. Our results support the conclusion that human BoDV-1 infections primarily lead to severe encephalitis with high mortality.
Sections du résumé
BACKGROUND
BACKGROUND
Borna disease virus 1 (BoDV-1) causes rare human infections within endemic regions in southern and eastern Germany. The infections reported to date have been linked to severe courses of encephalitis with high mortality and mostly irreversible symptoms. Whether BoDV-1 could act as a trigger for other neurological conditions, is, however, incompletely understood.
OBJECTIVES AND METHODS
OBJECTIVE
In this study, we addressed the question of whether the presentation of a clinically isolated syndrome (CIS) or of multiple sclerosis (MS) might be associated with a milder course of BoDV-1 infections. Serum samples of 100 patients with CIS or MS diagnosed at a tertiary neurological care center within an endemic region in southern Germany and of 50 control patients suffering from headache were retrospectively tested for BoDV-1 infections.
RESULTS
RESULTS
In none of the tested sera, confirmed positive results of anti-BoDV-1-IgG antibodies were retrieved. Our results support the conclusion that human BoDV-1 infections primarily lead to severe encephalitis with high mortality.
Identifiants
pubmed: 37814203
doi: 10.1007/s15010-023-02099-4
pii: 10.1007/s15010-023-02099-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University Hospital Regensburg
ID : ReForM-A program
Organisme : German Federal Ministry of Education and Research (BMBF)
ID : 01KI2002
Organisme : Bavarian Ministry of Health
ID : Bornavirus - Focal Point Bavaria 2.0
Organisme : Bundesministerium für Bildung und Forschung
ID : EXC 2145 SyNergy - ID 390857198
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : EXC 2145 SyNergy - ID 390857198
Informations de copyright
© 2023. The Author(s).
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