Serum uric acid is independently associated with hypertension in patients with polymyositis and dermatomyositis.
dermatomyositis
hypertension
polymyositis
uric acid
Journal
Journal of clinical hypertension (Greenwich, Conn.)
ISSN: 1751-7176
Titre abrégé: J Clin Hypertens (Greenwich)
Pays: United States
ID NLM: 100888554
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
07
09
2023
received:
16
05
2023
accepted:
08
09
2023
medline:
9
11
2023
pubmed:
10
10
2023
entrez:
10
10
2023
Statut:
ppublish
Résumé
Serum uric acid (UA), as an antioxidant, has been associated with hypertension in the general population. Hypertension is highly prevalent in patients with polymyositis and dermatomyositis (PM/DM). Owning elevated levels of reactive oxygen species, patients with PM/DM have lower concentrations of UA in comparison with healthy people. We explored a potential association between UA levels and hypertension in PM/DM and evaluated whether this association is independent of hypertension risk factors, PM/DM characteristics and relevant drugs. A total of 472 PM/DM patients were assessed. UA and related laboratory data were measured. Demographic, hypertension-related factors, PM/DM characteristics and drug use were assessed as potential covariates. Results were analyzed using logistic models to test the independence of the association between UA and hypertension. UA levels were higher in hypertension subjects compared to non-hypertensive PM/DM patients [284.70 (239.93-357.38) vs 264.00(222.50-322.75), p = .017]. When adjusted for hypertension risk factors, PM/DM characteristics and drugs, the odds of being a hypertensive PM/DM patient per 1 μmol/L UA increase were significantly increased: odds ratio = 1.473 (95% confidence interval:1.063-2.042, p = .020). This cross-sectional study suggests that UA levels are independently associated with hypertension in PM/DM patients.
Identifiants
pubmed: 37814496
doi: 10.1111/jch.14730
pmc: PMC10631100
doi:
Substances chimiques
Uric Acid
268B43MJ25
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1019-1026Subventions
Organisme : Chengdu High-level Key Clinical Specialty Construction Project
Informations de copyright
© 2023 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC.
Références
J Am Soc Nephrol. 2005 Dec;16(12):3553-62
pubmed: 16251237
Int J Neurosci. 2017 Jul;127(7):617-623
pubmed: 27485272
PPAR Res. 2013;2013:329862
pubmed: 23690758
Muscle Nerve. 2012 May;45(5):676-83
pubmed: 22499094
Biomed Res Int. 2019 Jul 02;2019:9792412
pubmed: 31355289
J Hypertens. 2023 Dec 1;41(12):1874-2071
pubmed: 37345492
Curr Hypertens Rev. 2015;11(2):132-42
pubmed: 26022210
Indian J Endocrinol Metab. 2019 Jan-Feb;23(1):134-139
pubmed: 31016168
Ann Rheum Dis. 2015 Jul;74(7):1340-6
pubmed: 26063809
Exp Physiol. 2017 Jun 1;102(6):614-615
pubmed: 28568964
Kidney Int. 2005 Jan;67(1):237-47
pubmed: 15610247
Curr Hypertens Rep. 2014 Sep;16(9):477
pubmed: 25097114
Ann Intern Med. 1980 Dec;93(6):817-21
pubmed: 7447188
Biomedicine (Taipei). 2018 Sep;8(3):16
pubmed: 30141403
N Engl J Med. 1975 Feb 20;292(8):403-7
pubmed: 1089199
BMC Res Notes. 2013 Sep 21;6:373
pubmed: 24053215
Arthritis Rheum. 2005 Jun;52(6):1824-35
pubmed: 15934115
J Clin Hypertens (Greenwich). 2023 Nov;25(11):1019-1026
pubmed: 37814496
Arthritis Care Res (Hoboken). 2011 Jan;63(1):102-10
pubmed: 20824805
Int J Rheum Dis. 2010 May;13(2):132-7
pubmed: 20536597
Clin Immunol Immunopathol. 1998 Jun;87(3):240-7
pubmed: 9646833
J Hypertens. 2008 Feb;26(2):269-75
pubmed: 18192841
Diabetol Metab Syndr. 2012 Apr 04;4:12
pubmed: 22475652
Diabetes. 2014 Mar;63(3):976-81
pubmed: 24353177
J Hypertens. 1999 Jul;17(7):869-72
pubmed: 10419058
Free Radic Biol Med. 1993 Jun;14(6):615-31
pubmed: 8325534
Arthritis Care Res (Hoboken). 2015 May;67(6):848-54
pubmed: 25418360
Am J Physiol Renal Physiol. 2002 Jun;282(6):F991-7
pubmed: 11997315
Proc Natl Acad Sci U S A. 1981 Nov;78(11):6858-62
pubmed: 6947260
Redox Biol. 2021 Oct;46:102108
pubmed: 34438260
Kidney Int. 2020 Nov;98(5):1149-1159
pubmed: 32650020
Antioxid Redox Signal. 2007 Dec;9(12):2277-93
pubmed: 17979528
Can J Physiol Pharmacol. 2020 Mar;98(3):139-146
pubmed: 31518503
Kidney Int. 2005 May;67(5):1739-42
pubmed: 15840020
Curr Rheumatol Rep. 2011 Apr;13(2):160-6
pubmed: 21234729
N Engl J Med. 1975 Feb 13;292(7):344-7
pubmed: 1090839
JAMA. 2008 Aug 27;300(8):924-32
pubmed: 18728266
Indian J Clin Biochem. 2009 Apr;24(2):205-7
pubmed: 23105835
J Physiol. 2011 May 1;589(Pt 9):2139-45
pubmed: 21320885
QJM. 2011 Dec;104(12):1015-24
pubmed: 21908382
PLoS One. 2014 Dec 01;9(12):e114259
pubmed: 25437867
J Clin Hypertens (Greenwich). 2013 Jun;15(6):435-42
pubmed: 23730993
J Appl Physiol (1985). 2007 May;102(5):1850-5
pubmed: 17303704
J Biol Chem. 2014 Jan 3;289(1):485-509
pubmed: 24220031
Hypertension. 2003 Jun;41(6):1183-90
pubmed: 12707287
Clin Cardiol. 2012 Nov;35(11):686-91
pubmed: 22847365
J Biol Chem. 1991 May 5;266(13):8604-8
pubmed: 2022672
Hypertension. 2013 Jul;62(1):209-15
pubmed: 23630949
Physiol Rev. 2017 Jul 1;97(3):1127-1164
pubmed: 28566539
Nephron Exp Nephrol. 2012;121(3-4):e71-8
pubmed: 23235493