Matrix density regulates adipocyte phenotype.
Adipocyte
adipogenesis
adipose tissue
hydrogel
matrix
Journal
Adipocyte
ISSN: 2162-397X
Titre abrégé: Adipocyte
Pays: United States
ID NLM: 101567863
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
medline:
2
11
2023
pubmed:
10
10
2023
entrez:
10
10
2023
Statut:
ppublish
Résumé
Alterations of the extracellular matrix contribute to adipose tissue dysfunction in metabolic disease. We studied the role of matrix density in regulating human adipocyte phenotype in a tunable hydrogel culture system. Lipid accumulation was maximal in intermediate hydrogel density of 5 weight %, relative to 3% and 10%. Adipogenesis and lipid and oxidative metabolic gene pathways were enriched in adipocytes in 5% relative to 3% hydrogels, while fibrotic gene pathways were enriched in 3% hydrogels. These data demonstrate that the intermediate density matrix promotes a more adipogenic, less fibrotic adipocyte phenotype geared towards increased lipid and aerobic metabolism. These observations contribute to a growing literature describing the role of matrix density in regulating adipose tissue function.
Identifiants
pubmed: 37815174
doi: 10.1080/21623945.2023.2268261
pmc: PMC10566443
doi:
Substances chimiques
Hydrogels
0
Lipids
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2268261Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK115190
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK132785
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK090262
Pays : United States
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