Axonal Transport of Lysosomes Is Unaffected in Glucocerebrosidase-Inhibited iPSC-Derived Forebrain Neurons.

Male Humans Glucosylceramidase / genetics Neurodegenerative Diseases / metabolism Axonal Transport Induced Pluripotent Stem Cells Neurons / metabolism Prosencephalon / metabolism Lysosomes / metabolism alpha-Synuclein / metabolism
axonal transport conduritol B epoxide glucocerebrosidase lysosomes

Journal

eNeuro
ISSN: 2373-2822
Titre abrégé: eNeuro
Pays: United States
ID NLM: 101647362

Informations de publication

Date de publication:
10 2023
Historique:
received: 22 02 2023
revised: 18 09 2023
accepted: 20 09 2023
medline: 23 10 2023
pubmed: 11 10 2023
entrez: 10 10 2023
Statut: epublish

Résumé

Lysosomes are acidic organelles that traffic throughout neurons delivering catabolic enzymes to distal regions of the cell and maintaining degradative demands. Loss of function mutations in the gene

Identifiants

DOI: 10.1523/ENEURO.0079-23.2023 PMID: 37816595 PMC: PMC10576257
pubmed: 37816595
pii: 10/10/ENEURO.0079-23.2023
doi: 10.1523/ENEURO.0079-23.2023
pmc: PMC10576257
pii:
doi:

Substances chimiques

Glucosylceramidase EC 3.2.1.45
alpha-Synuclein 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023 Keefe et al.

Déclaration de conflit d'intérêts

The authors declare no competing financial interests.

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Auteurs

A J Keefe (AJ)

Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.

D R Gabrych (DR)

Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.

Y Zhu (Y)

Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.

D J Vocadlo (DJ)

Centre for Cell Biology, Development, and Disease, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.

M A Silverman (MA)

Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada masilver@sfu.ca.
Centre for Cell Biology, Development, and Disease, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
ORCID: 0000-0001-6967-4917

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Axonal Transport of Lysosomes Is Unaffected in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucosidases › Glucosylceramidase › Axonal Transport of Lysosomes Is Unaffected in...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Axonal Transport of Lysosomes Is Unaffected in...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transport axonal › Axonal Transport of Lysosomes Is Unaffected in...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Axonal Transport of Lysosomes Is Unaffected in...
questionsmedicales.fr › Cellules › Neurones › Axonal Transport of Lysosomes Is Unaffected in...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Axonal Transport of Lysosomes Is Unaffected in...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › Axonal Transport of Lysosomes Is Unaffected in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › alpha-Synucléine › Axonal Transport of Lysosomes Is Unaffected in...