Pre-clinical lung squamous cell carcinoma mouse models to identify novel biomarkers and therapeutic interventions.
animal models
genetic and epigenetic alterations
lung cancer
risk factors
squamous cell carcinoma
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2023
2023
Historique:
received:
17
07
2023
accepted:
29
08
2023
medline:
11
10
2023
pubmed:
11
10
2023
entrez:
11
10
2023
Statut:
epublish
Résumé
Primary lung carcinoma or lung cancer (LC) is classified into small-cell or non-small-cell (NSCLC) lung carcinoma. Lung squamous cell carcinoma (LSCC) is the second most common subtype of NSCLC responsible for 30% of all LCs, and its survival remains low with only 24% of patients living for five years or longer post-diagnosis primarily due to the advanced stage of tumors at the time of diagnosis. The pathogenesis of LSCC is still poorly understood and has hampered the development of effective diagnostics and therapies. This review highlights the known risk factors, genetic and epigenetic alterations, miRNA biomarkers linked to the development and diagnosis of LSCC and the lack of therapeutic strategies to target specifically LSCC. We will also discuss existing animal models of LSCC including carcinogen induced, transgenic and xenograft mouse models, and their advantages and limitations along with the chemopreventive studies and molecular studies conducted using them. The importance of developing new and improved mouse models will also be discussed that will provide further insights into the initiation and progression of LSCC, and enable the identification of new biomarkers and therapeutic targets.
Identifiants
pubmed: 37817767
doi: 10.3389/fonc.2023.1260411
pmc: PMC10560855
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1260411Informations de copyright
Copyright © 2023 Sahu, Donovan, Paudel, Pickles, Chimankar, Kim, Horvart, Dua, Ieni, Nucera, Bielefeldt-Ohmann, Mazilli, Caramori, Lyons and Hansbro.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Br J Pharmacol. 2016 Feb;173(4):635-48
pubmed: 26013585
Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25
pubmed: 14685170
Drug Deliv Transl Res. 2017 Feb;7(1):168-178
pubmed: 27848224
Oncotarget. 2017 Jul 28;8(49):86897-86907
pubmed: 29156844
Acta Vet Scand. 2017 Oct 24;59(1):71
pubmed: 29065898
Eur Respir Rev. 2017 Oct 25;26(146):
pubmed: 29070578
Cancer Lett. 2011 Jan 1;300(1):79-86
pubmed: 20926182
Mol Cancer Ther. 2010 Nov;9(11):3074-82
pubmed: 21045137
Cancer Prev Res (Phila). 2016 Jan;9(1):96-104
pubmed: 26542061
Mol Cancer. 2008 Jul 10;7:62
pubmed: 18616821
Cancer Sci. 2016 Feb;107(2):123-32
pubmed: 26663681
PLoS One. 2015 Apr 10;10(4):e0122823
pubmed: 25860262
Future Med Chem. 2020 Apr;12(7):567-570
pubmed: 32175774
Nucleic Acids Res. 2019 Jan 8;47(D1):D941-D947
pubmed: 30371878
Lancet Respir Med. 2020 Jun;8(6):585-596
pubmed: 32526187
Cancer Prev Res (Phila). 2012 Feb;5(2):283-9
pubmed: 22086679
Jpn J Clin Oncol. 2008 Aug;38(8):534-9
pubmed: 18689853
Semin Oncol. 2017 Aug;44(4):288-300
pubmed: 29526258
Lancet Oncol. 2021 Feb;22(2):198-211
pubmed: 33476593
Cancer Prev Res (Phila). 2015 Oct;8(10):895-904
pubmed: 26276745
Br J Cancer. 1997;75(9):1302-8
pubmed: 9155050
Vet Immunol Immunopathol. 2016 Jan;169:15-26
pubmed: 26827834
PLoS One. 2010 Feb 11;5(2):e9162
pubmed: 20161782
Lung Cancer. 2015 Nov;90(2):121-7
pubmed: 26363803
Onco Targets Ther. 2020 Sep 22;13:9305-9321
pubmed: 33061419
Oncotarget. 2017 May 23;8(21):34032-34044
pubmed: 28415565
Cancer Discov. 2011 Jun;1(1):78-89
pubmed: 22328973
J Thorac Oncol. 2016 Apr;11(4):524-36
pubmed: 26845193
Cancer Lett. 2015 Feb 1;357(1):179-185
pubmed: 25444907
Ann Oncol. 2010 Mar;21(3):562-567
pubmed: 19767315
Cancer Res. 2007 Apr 1;67(7):3475-82
pubmed: 17389758
Cancer Prev Res (Phila). 2015 Jan;8(1):77-85
pubmed: 25403850
Eur Rev Med Pharmacol Sci. 2018 Jun;22(12):3819-3825
pubmed: 29949158
Gan. 1977 Jun;68(3):343-52
pubmed: 913956
Ann Oncol. 2017 Jul 1;28(suppl_4):iv1-iv21
pubmed: 28881918
N Engl J Med. 1961 Aug 10;265:253-67
pubmed: 13685078
Lung Cancer. 2001 Feb-Mar;31(2-3):139-48
pubmed: 11165392
Pathology. 2011 Dec;43(7):719-24
pubmed: 22027741
Oncotarget. 2017 Dec 27;9(7):7424-7441
pubmed: 29484121
J Thorac Oncol. 2015 Mar;10(3):446-53
pubmed: 25695220
Nature. 2007 Aug 16;448(7155):807-10
pubmed: 17676035
Lung Cancer. 2014 Sep;85(3):351-60
pubmed: 25064415
Cancer Res. 2000 Nov 1;60(21):5954-8
pubmed: 11085511
Clin Cancer Res. 2011 Nov 1;17(21):6802-11
pubmed: 21890451
Thorax. 2013 Jun;68(6):551-64
pubmed: 23399908
Thorax. 2004 Aug;59(8):679-81
pubmed: 15282388
Nucleic Acids Res. 1998 Aug 1;26(15):3453-9
pubmed: 9671804
Curr Probl Cancer. 2020 Aug;44(4):100540
pubmed: 32007320
J Thorac Oncol. 2019 Jan;14(1):25-36
pubmed: 30253973
Cancer Res. 2004 Mar 1;64(5):1647-54
pubmed: 14996723
Am J Respir Crit Care Med. 2015 May 1;191(9):1012-23
pubmed: 25751541
Lancet Oncol. 2020 Dec;21(12):1589-1601
pubmed: 33125909
Crit Rev Oncol Hematol. 2020 Apr;148:102862
pubmed: 32062311
Cancer Prev Res (Phila). 2009 Jul;2(7):634-40
pubmed: 19584077
Nat Genet. 2016 Jun;48(6):607-16
pubmed: 27158780
Cancer Cell. 2010 Jan 19;17(1):89-97
pubmed: 20129250
Cancer Biol Ther. 2009 Nov;8(21):2042-50
pubmed: 19755855
Cancer Cell. 2016 Oct 10;30(4):519-532
pubmed: 27728803
Cancer Res. 2008 Sep 1;68(17):6913-21
pubmed: 18757405
Clin Cancer Res. 2020 Jul 1;26(13):3431-3442
pubmed: 32209571
BMC Cancer. 2011 Apr 20;11:147
pubmed: 21507233
Nat Med. 2019 Mar;25(3):517-525
pubmed: 30664780
Ann Oncol. 2020 Feb;31(2):191-201
pubmed: 31959336
Sultan Qaboos Univ Med J. 2013 Aug;13(3):345-58
pubmed: 23984018
Pathol Int. 2007 Oct;57(10):664-71
pubmed: 17803655
J Biol Chem. 2010 Jun 11;285(24):18575-85
pubmed: 20360610
Lung Cancer. 2010 Sep;69(3):279-83
pubmed: 20018398
J Thorac Oncol. 2010 Mar;5(3):305-13
pubmed: 20107422
Clin Cancer Res. 2011 Jul 1;17(13):4494-503
pubmed: 21610147
Cancer Cell. 2013 Apr 15;23(4):527-40
pubmed: 23597566
J Transl Med. 2018 May 22;16(1):138
pubmed: 29788985
Dis Model Mech. 2022 Jan 1;15(1):
pubmed: 34870316
Lung Cancer. 2011 Feb;71(2):182-5
pubmed: 20554345
Lung Cancer. 2014 Apr;84(1):13-22
pubmed: 24524818
Cancer Metastasis Rev. 2013 Jun;32(1-2):77-82
pubmed: 23229817
Int J Cancer. 2012 Sep 1;131(5):1210-9
pubmed: 22052329
Nat Rev Cancer. 2014 Aug;14(8):535-46
pubmed: 25056707
Lancet Respir Med. 2021 Sep;9(9):1030-1049
pubmed: 34411511
Lung Cancer. 2007 Oct;58(1):159-60
pubmed: 17681398
Sci Transl Med. 2011 Jan 5;3(64):64rv1
pubmed: 21209413
Immunity. 2018 Oct 16;49(4):764-779.e9
pubmed: 30332632
Am J Respir Crit Care Med. 2011 Oct 15;184(8):866-7
pubmed: 22003145
Ann Glob Health. 2019 Jan 22;85(1):
pubmed: 30741509
Expert Opin Drug Discov. 2014 Jun;9(6):629-45
pubmed: 24754714
J Natl Cancer Inst. 1971 Sep;47(3):697-701
pubmed: 5157586
PLoS One. 2010 Sep 03;5(9):e12560
pubmed: 20838434
J Thorac Oncol. 2012 May;7(5):924-33
pubmed: 22722794
Cancer Prev Res (Phila). 2021 Mar;14(3):307-312
pubmed: 33115782
J Cancer Res Clin Oncol. 1988;114(3):245-9
pubmed: 3384841
J Pathol Transl Med. 2018 Sep;52(5):283-289
pubmed: 30235512
Int J Cancer. 2017 Feb 1;140(3):662-673
pubmed: 27750381
Molecules. 2021 Mar 05;26(5):
pubmed: 33807509
Cancer. 2006 May 15;106(10):2190-9
pubmed: 16598757
J Clin Oncol. 2012 Jun 10;30(17):2055-62
pubmed: 22547591
Nat Rev Cancer. 2013 Apr;13(4):233-45
pubmed: 23467302
Lancet. 2014 Aug 23;384(9944):665-73
pubmed: 24933332
BMC Cancer. 2010 Nov 03;10:600
pubmed: 21047392
Cancer Prev Res (Phila). 2019 Aug;12(8):507-516
pubmed: 31101634
J Clin Oncol. 2008 Jul 20;26(21):3543-51
pubmed: 18506025
Cell. 2012 Mar 30;149(1):246-246.e1
pubmed: 22464334
Cancer Res. 2009 Jul 15;69(14):5776-83
pubmed: 19584273
Cancer Cell. 2014 May 12;25(5):590-604
pubmed: 24794706
Mol Biol (Mosk). 2006 Nov-Dec;40(6):1047-54
pubmed: 17209433
Sci Rep. 2023 Jan 30;13(1):1655
pubmed: 36717588
Respirology. 2017 Jan;22(1):21-32
pubmed: 27731525
J Thorac Oncol. 2012 Jan;7(1):20-33
pubmed: 22011669
Cancer Chemother Pharmacol. 2014 Dec;74(6):1297-305
pubmed: 25344762
PLoS One. 2013;8(3):e58714
pubmed: 23527012
J Natl Cancer Inst. 1999 Jul 21;91(14):1194-210
pubmed: 10413421
Front Oncol. 2015 Mar 03;5:52
pubmed: 25785245
Eur Respir J. 2012 Nov;40(5):1228-37
pubmed: 22653775
Nat Commun. 2019 Apr 23;10(1):1856
pubmed: 31015447
Cancer Prev Res (Phila). 2013 Jun;6(6):530-9
pubmed: 23550152
J Thorac Oncol. 2021 Aug;16(8):1250-1266
pubmed: 34304854
Oncotarget. 2017 Mar 21;8(12):18885-18900
pubmed: 27935865
Lancet. 2009 Oct 24;374(9699):1432-40
pubmed: 19767093
N Engl J Med. 2015 Jul 9;373(2):123-35
pubmed: 26028407
Nature. 2012 Sep 27;489(7417):519-25
pubmed: 22960745
Mol Cancer. 2017 May 22;16(1):93
pubmed: 28532501
Cancer Med. 2015 Feb;4(2):201-11
pubmed: 25470237
DNA Repair (Amst). 2008 Aug 2;7(8):1352-63
pubmed: 18555750
Mod Pathol. 2010 Aug;23(8):1157-64
pubmed: 20526284
Folia Histochem Cytobiol. 2009;47(2):275-80
pubmed: 19926549
Sci Rep. 2018 Oct 18;8(1):15363
pubmed: 30337605
Oncol Lett. 2018 Jun;15(6):8589-8603
pubmed: 29805594
Mol Cancer Ther. 2017 Aug;16(8):1610-1622
pubmed: 28611104
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Cancer Genet Cytogenet. 2010 Jul 15;200(2):127-33
pubmed: 20620595
PLoS One. 2014 Jul 16;9(7):e101802
pubmed: 25028925
Clin Chem. 2002 Nov;48(11):1931-7
pubmed: 12406978
Drug Deliv Transl Res. 2018 Feb;8(1):97-110
pubmed: 29185148
Cancer Res. 1992 Sep 1;52(17):4799-804
pubmed: 1324794
Genes Chromosomes Cancer. 2011 Oct;50(10):830-6
pubmed: 21755566
J Clin Oncol. 2010 May 1;28(13):2174-80
pubmed: 20351332
Int J Cancer. 2012 Dec 15;131(12):2724-32
pubmed: 22945513
Lancet. 2011 Sep 10;378(9795):1015-26
pubmed: 21907865
Clin Cancer Res. 2010 Jul 15;16(14):3743-53
pubmed: 20534738
Lung. 2009 Nov-Dec;187(6):401-11
pubmed: 19795170
J Thorac Oncol. 2015 Sep;10(9):1243-1260
pubmed: 26291008
Sci Transl Med. 2010 Dec 15;2(62):62ra93
pubmed: 21160078
J Cancer Res Clin Oncol. 2011 Apr;137(4):557-66
pubmed: 20508945
Mol Biol Rep. 2013 Jan;40(1):309-25
pubmed: 23086271
Immunol Rev. 2013 May;253(1):198-215
pubmed: 23550648
Cell Rep. 2014 Jul 10;8(1):40-9
pubmed: 24953650