DNA methylation-based diagnosis confirmation in a pediatric patient with low-grade glioma: a case report.
CNS tumors
DNA methylation
Sanger sequencing
children
molecular diagnostics
pediatric oncology
pilocytic astrocytoma
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2023
2023
Historique:
received:
11
07
2023
accepted:
04
09
2023
medline:
11
10
2023
pubmed:
11
10
2023
entrez:
11
10
2023
Statut:
epublish
Résumé
Central nervous system (CNS) tumors in children comprise a highly heterogenous and complex group of diseases. Historically, diagnosis and confirmation of these tumors were routinely based on histological examination. However, recently obtained data demonstrate that such a diagnostic approach is not completely accurate and could lead to misdiagnosis. Also, in recent times, the quantity and quality of molecular diagnostic methods have greatly improved, which influences the current classification methods and treatment approach for pediatric CNS tumors. Nowadays, molecular methods, such as DNA methylation profiling, are an integral part of diagnosing brain and spinal tumors in children. In this paper, we present the case of an infant with a posterior fossa tumor who demonstrated a non-specific morphology and whose diagnosis was verified only after DNA methylation.
Identifiants
pubmed: 37818165
doi: 10.3389/fped.2023.1256876
pmc: PMC10561295
doi:
Types de publication
Case Reports
Langues
eng
Pagination
1256876Informations de copyright
© 2023 Morgacheva, Ryzhova, Zheludkova, Belogurova and Dinikina.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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