Immunometabolic regulation during the presence of microorganisms and parasitoids in insects.
Drosophila
IMD/Toll
immunometabolism
insects
insulin signaling
pathogenic
symbiotic bacteria
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
27
03
2022
accepted:
04
09
2023
medline:
1
11
2023
pubmed:
11
10
2023
entrez:
11
10
2023
Statut:
epublish
Résumé
Multicellular organisms live in environments containing diverse nutrients and a wide variety of microbial communities. On the one hand, the immune response of organisms can protect from the intrusion of exogenous microorganisms. On the other hand, the dynamic coordination of anabolism and catabolism of organisms is a necessary factor for growth and reproduction. Since the production of an immune response is an energy-intensive process, the activation of immune cells is accompanied by metabolic transformations that enable the rapid production of ATP and new biomolecules. In insects, the coordination of immunity and metabolism is the basis for insects to cope with environmental challenges and ensure normal growth, development and reproduction. During the activation of insect immune tissues by pathogenic microorganisms, not only the utilization of organic resources can be enhanced, but also the activated immune cells can usurp the nutrients of non-immune tissues by generating signals. At the same time, insects also have symbiotic bacteria in their body, which can affect insect physiology through immune-metabolic regulation. This paper reviews the research progress of insect immune-metabolism regulation from the perspective of insect tissues, such as fat body, gut and hemocytes. The effects of microorganisms (pathogenic bacteria/non-pathogenic bacteria) and parasitoids on immune-metabolism were elaborated here, which provide guidance to uncover immunometabolism mechanisms in insects and mammals. This work also provides insights to utilize immune-metabolism for the formulation of pest control strategies.
Identifiants
pubmed: 37818375
doi: 10.3389/fimmu.2023.905467
pmc: PMC10560992
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
905467Informations de copyright
Copyright © 2023 Li, Wang, Tian, Toufeeq and Huang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
PLoS Genet. 2009 Apr;5(4):e1000460
pubmed: 19390610
J Innate Immun. 2012;4(3):273-83
pubmed: 22237424
Cell Host Microbe. 2012 Jul 19;12(1):60-70
pubmed: 22817988
Nat Immunol. 2009 Sep;10(9):949-57
pubmed: 19668222
Nat Rev Microbiol. 2013 Sep;11(9):615-26
pubmed: 23893105
Dev Cell. 2003 Sep;5(3):441-50
pubmed: 12967563
Science. 2011 Nov 4;334(6056):670-4
pubmed: 22053049
Genome Biol. 2006;7(8):232
pubmed: 16930467
PLoS Pathog. 2018 Apr 27;14(4):e1007022
pubmed: 29702691
Nature. 2006 Dec 14;444(7121):860-7
pubmed: 17167474
Dev Comp Immunol. 2016 May;58:95-101
pubmed: 26748247
Curr Biol. 2004 May 25;14(10):885-90
pubmed: 15186745
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20853-8
pubmed: 19861550
Dev Comp Immunol. 2018 Jun;83:130-143
pubmed: 29225005
Cell Host Microbe. 2008 Aug 14;4(2):147-58
pubmed: 18692774
Sci Rep. 2021 Dec 2;11(1):23316
pubmed: 34857836
Nat Rev Cancer. 2007 Mar;7(3):182-91
pubmed: 17318211
J Intern Med. 2010 Jun;267(6):543-60
pubmed: 20210843
Cell Host Microbe. 2018 Jul 11;24(1):109-119.e6
pubmed: 30008290
Open Biol. 2016 Feb;6(2):150155
pubmed: 26887408
Mol Metab. 2016 Dec 08;6(2):174-184
pubmed: 28180059
ISME J. 2010 Feb;4(2):242-52
pubmed: 19907504
J Immunol. 2011 Jan 15;186(2):649-56
pubmed: 21209287
Appl Environ Microbiol. 2007 Jun;73(11):3470-9
pubmed: 17400769
Exp Cell Res. 2005 Apr 15;305(1):145-55
pubmed: 15777795
Genes Dev. 2009 Oct 1;23(19):2333-44
pubmed: 19797770
PLoS Genet. 2010 Feb 26;6(2):e1000857
pubmed: 20195512
Front Immunol. 2020 Apr 28;11:763
pubmed: 32411148
Proc Biol Sci. 2006 Sep 7;273(1598):2097-106
pubmed: 16901827
PLoS One. 2008 Aug 22;3(8):e3041
pubmed: 18725942
Curr Opin Immunol. 2003 Feb;15(1):12-9
pubmed: 12495727
Dev Cell. 2010 Oct 19;19(4):491-505
pubmed: 20951342
Proc Natl Acad Sci U S A. 2008 May 13;105(19):7088-93
pubmed: 18458334
Immunity. 2017 Jul 18;47(1):93-106.e7
pubmed: 28723556
Annu Rev Immunol. 2007;25:697-743
pubmed: 17201680
Integr Zool. 2021 May;16(3):313-323
pubmed: 33704889
J Insect Physiol. 2019 May - Jun;115:33-39
pubmed: 30953618
J Cardiovasc Dev Dis. 2016 Apr 12;3(2):
pubmed: 29367564
Pest Manag Sci. 2020 Jun;76(6):2180-2189
pubmed: 31960570
PLoS One. 2014 Apr 14;9(4):e94729
pubmed: 24733183
Elife. 2014 Jul 15;3:e02964
pubmed: 25027439
Nat Rev Immunol. 2011 Aug 05;11(9):625-32
pubmed: 21818124
Cell Rep. 2017 Aug 22;20(8):1784-1793
pubmed: 28834743
PLoS One. 2012;7(6):e38544
pubmed: 22685581
Nat Immunol. 2003 May;4(5):478-84
pubmed: 12692550
Immunity. 2015 Mar 17;42(3):419-30
pubmed: 25786174
Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7099-7104
pubmed: 29915049
Science. 1982 Jul 2;217(4554):57-9
pubmed: 17739983
G3 (Bethesda). 2014 Mar 12;4(5):839-50
pubmed: 24622332
Nat Rev Endocrinol. 2014 Sep;10(9):540-52
pubmed: 24958311
Insect Sci. 2022 Apr;29(2):399-410
pubmed: 34724344
PLoS Biol. 2004 Dec;2(12):e418
pubmed: 15562316
Dev Comp Immunol. 2014 Jan;42(1):111-23
pubmed: 23764256
Dev Comp Immunol. 2019 Feb;91:85-92
pubmed: 30385314
Elife. 2016 Sep 01;5:
pubmed: 27585295
BMC Genomics. 2016 Nov 25;17(1):975
pubmed: 27887564
Cell Host Microbe. 2018 Mar 14;23(3):338-352.e5
pubmed: 29503179
J Endotoxin Res. 2005;11(6):383-9
pubmed: 16303095
Insect Biochem Mol Biol. 2002 Oct;32(10):1295-309
pubmed: 12225920
EMBO J. 2002 Jun 17;21(12):3009-18
pubmed: 12065414
Parasit Vectors. 2015 Aug 19;8:424
pubmed: 26283222
Insect Mol Biol. 2010 Aug;19(4):481-8
pubmed: 20456506
Bioessays. 2013 Nov;35(11):965-73
pubmed: 24115022
J Invertebr Pathol. 1969 Nov;14(3):365-74
pubmed: 4904970
J Exp Biol. 2014 Jun 1;217(Pt 11):1894-901
pubmed: 24577449
Annu Rev Immunol. 2011;29:415-45
pubmed: 21219177
J Immunol. 2014 Apr 15;192(8):3455-62
pubmed: 24706930
Discov Med. 2021 Jan-Feb;31(162):37-44
pubmed: 34965370
Cell. 2004 May 14;117(4):421-6
pubmed: 15137936
ISME J. 2018 Apr;12(4):959-972
pubmed: 29358735
ISME J. 2020 Aug;14(8):1982-1993
pubmed: 32350409
Dev Cell. 2002 Nov;3(5):711-22
pubmed: 12431377
FEMS Microbiol Lett. 2008 Apr;281(2):215-20
pubmed: 18312577
Nat Rev Drug Discov. 2014 Jan;13(1):63-79
pubmed: 24336504
Nat Rev Microbiol. 2008 Oct;6(10):741-51
pubmed: 18794912
Science. 2012 Jun 8;336(6086):1262-7
pubmed: 22674330
Cell Host Microbe. 2012 Aug 16;12(2):153-65
pubmed: 22901536
Dev Biol. 2019 Oct 1;454(1):52-65
pubmed: 31228417
J Lipid Res. 2007 Dec;48(12):2736-50
pubmed: 17762044
Ecol Lett. 2013 Feb;16(2):214-8
pubmed: 23137173
Infect Immun. 2004 Jul;72(7):4114-26
pubmed: 15213157
Cell Metab. 2016 Apr 12;23(4):675-84
pubmed: 27076079
PLoS Biol. 2018 Jul 5;16(7):e2005710
pubmed: 29975680
Cell Host Microbe. 2015 Oct 14;18(4):445-55
pubmed: 26439865
Infect Immun. 2005 Jul;73(7):4161-70
pubmed: 15972506
J Innate Immun. 2010;2(4):371-8
pubmed: 20505310
Curr Biol. 2006 Oct 24;16(20):1977-85
pubmed: 17055976
Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14614-9
pubmed: 9405661
PLoS One. 2014 Jan 07;9(1):e84865
pubmed: 24409310
Comp Biochem Physiol B Biochem Mol Biol. 2001 May;129(1):1-15
pubmed: 11337247
Nat Rev Immunol. 2008 Dec;8(12):923-34
pubmed: 19029988
Insect Biochem Mol Biol. 2019 Feb;105:33-42
pubmed: 30602123
Science. 2010 Jul 9;329(5988):212-5
pubmed: 20616278
mBio. 2016 Jul 12;7(4):
pubmed: 27406568
Sci Rep. 2020 Feb 7;10(1):2096
pubmed: 32034183
Biol Open. 2019 Jul 19;8(7):
pubmed: 31278163
EMBO Rep. 2015 Dec;16(12):1664-72
pubmed: 26412855
Mol Cell Endocrinol. 2018 Feb 5;461:165-177
pubmed: 28893568
Insect Biochem Mol Biol. 2021 Aug;135:103609
pubmed: 34146686
J Exp Biol. 2013 Sep 1;216(Pt 17):3350-7
pubmed: 23685974
PLoS Pathog. 2021 Sep 16;17(9):e1009539
pubmed: 34529715
PLoS Biol. 2015 Apr 27;13(4):e1002135
pubmed: 25915062
Immunity. 2015 Jan 20;42(1):133-44
pubmed: 25601202
EMBO J. 2013 Nov 27;32(23):3017-28
pubmed: 24141879
Cell Microbiol. 2005 Mar;7(3):335-50
pubmed: 15679837
BMC Evol Biol. 2008 Mar 03;8:76
pubmed: 18315877
PLoS One. 2012;7(12):e50679
pubmed: 23272066
Cell Metab. 2011 Sep 7;14(3):403-14
pubmed: 21907145
Front Biosci. 2002 Mar 01;7:d619-40
pubmed: 11861210
Cell. 2001 Apr 20;105(2):165-8
pubmed: 11336665
Future Sci OA. 2017 Jun 26;3(3):FSO201
pubmed: 28884000
Cell Metab. 2018 Sep 4;28(3):449-462.e5
pubmed: 29937377
Cell Signal. 2014 Aug;26(8):1753-63
pubmed: 24704121
Elife. 2015 Feb 04;4:
pubmed: 25650737
EMBO J. 1995 Jul 17;14(14):3373-84
pubmed: 7628438
Parasitology. 2006 Feb;132(Pt 2):169-76
pubmed: 16197594
Science. 2007 Feb 16;315(5814):988-92
pubmed: 17303754
Mol Ecol. 2011 Mar;20(5):950-8
pubmed: 21255169
Heredity (Edinb). 2014 Apr;112(4):399-408
pubmed: 24281548
Nature. 2022 Mar;603(7901):477-481
pubmed: 35264789
Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9465-9
pubmed: 7568155
Cell. 2014 Mar 27;157(1):121-41
pubmed: 24679531
J Insect Physiol. 2018 May - Jun;107:167-174
pubmed: 29627353
J Immunol. 2012 Aug 15;189(4):1886-97
pubmed: 22772451
Annu Rev Entomol. 1997;42:525-50
pubmed: 15012322
Insect Biochem Mol Biol. 2022 Jul;146:103776
pubmed: 35526745
Cell Rep. 2014 Oct 9;9(1):32-39
pubmed: 25263551
Gut Microbes. 2016 May 3;7(3):189-200
pubmed: 26963409
J Mol Biol. 2014 Nov 25;426(23):3830-7
pubmed: 24735869
Curr Opin Insect Sci. 2018 Oct;29:21-26
pubmed: 30551821
Cell Host Microbe. 2009 Feb 19;5(2):200-11
pubmed: 19218090
Cell Metab. 2007 Aug;6(2):144-52
pubmed: 17681150
Arthritis Res Ther. 2014 Nov 13;16 Suppl 2:S4
pubmed: 25608958
mBio. 2014 May 27;5(3):e01117-14
pubmed: 24865556
Insect Biochem Mol Biol. 2019 Jun;109:31-42
pubmed: 30959109
Genes (Basel). 2017 Feb 25;8(3):
pubmed: 28245597
J Bacteriol. 2011 Oct;193(19):5587-8
pubmed: 21914892
Science. 2008 Feb 8;319(5864):777-82
pubmed: 18218863
J Clin Invest. 1990 Jun;85(6):1896-904
pubmed: 2347917
Int J Parasitol. 2011 Aug 15;41(10):1053-61
pubmed: 21782817
Science. 2003 Feb 28;299(5611):1351-4
pubmed: 12610295
Nat Immunol. 2008 Oct;9(10):1165-70
pubmed: 18724373
Science. 2003 Feb 28;299(5611):1346-51
pubmed: 12610294
Clin Transl Immunology. 2016 Apr 22;5(4):e73
pubmed: 27195116
Gut Microbes. 2012 Jul-Aug;3(4):289-306
pubmed: 22572875
Dev Biol. 2001 Feb 15;230(2):243-57
pubmed: 11161576
J Dev Biol. 2017 Dec 01;5(4):
pubmed: 29615570
Annu Rev Immunol. 2014;32:609-34
pubmed: 24655299
PLoS Genet. 2011 Sep;7(9):e1002272
pubmed: 21966276
Cell. 2013 Oct 10;155(2):435-47
pubmed: 24075010
Insects. 2012 Aug 14;3(3):743-62
pubmed: 26466627
Front Microbiol. 2016 Feb 17;7:185
pubmed: 26925050
Insect Mol Biol. 2007 Apr;16(2):143-54
pubmed: 17298560
Cell. 2017 May 4;169(4):570-586
pubmed: 28475890
Trends Endocrinol Metab. 2009 Apr;20(3):100-6
pubmed: 19251431
Infect Immun. 2007 Apr;75(4):1565-76
pubmed: 17220307
Cell. 1999 Jun 25;97(7):865-75
pubmed: 10399915
J Immunol. 2019 May 1;202(9):2747-2759
pubmed: 30902902
Cell Metab. 2018 Feb 6;27(2):362-377.e8
pubmed: 29290388
Comp Biochem Physiol B. 1973 Nov 15;46(3):595-602
pubmed: 4754772
Acta Trop. 2004 Nov-Dec;92(3):225-30
pubmed: 15533291
PLoS Pathog. 2006 Feb;2(2):e14
pubmed: 16518472
Elife. 2019 Oct 14;8:
pubmed: 31609200
Appl Environ Microbiol. 2014 Jan;80(2):470-7
pubmed: 24185857
Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21528-33
pubmed: 23236133
Cell Host Microbe. 2015 Feb 11;17(2):191-204
pubmed: 25639794
Front Neurosci. 2013 Feb 12;7:12
pubmed: 23407678
Mol Immunol. 2008 Feb;45(3):810-7
pubmed: 17681604
Trends Immunol. 2017 Jun;38(6):395-406
pubmed: 28396078
Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10496-501
pubmed: 20498052
Microbiol Mol Biol Rev. 2005 Mar;69(1):12-50
pubmed: 15755952
J Insect Physiol. 2016 Mar;86:17-24
pubmed: 26699661
Nat Rev Endocrinol. 2016 Jan;12(1):15-28
pubmed: 26553134
Nat Rev Mol Cell Biol. 2003 Nov;4(11):897-901
pubmed: 14625539
Genetics. 2018 Oct;210(2):357-396
pubmed: 30287514
Annu Rev Entomol. 2009;54:285-302
pubmed: 19067633
PLoS One. 2013 Aug 13;8(8):e70749
pubmed: 23967097
Science. 2011 Oct 21;334(6054):362-5
pubmed: 22021855
Dev Comp Immunol. 2016 Nov;64:65-74
pubmed: 26872544
Nat Immunol. 2013 Jul;14(7):668-75
pubmed: 23778794
Cell. 2012 Sep 28;151(1):123-37
pubmed: 23021220
Appl Environ Microbiol. 2019 Jan 9;85(2):
pubmed: 30389767
Nature. 2017 Feb 8;542(7640):177-185
pubmed: 28179656
Pharmacol Ther. 2006 Nov;112(2):358-404
pubmed: 16784779
Cell Rep. 2015 Dec 15;13(10):2048-55
pubmed: 26628374
Cell Metab. 2017 Jul 5;26(1):110-130
pubmed: 28625867
Mol Cell Biol. 2017 Dec 29;38(2):
pubmed: 29084810
Cell. 2014 Jan 16;156(1-2):109-22
pubmed: 24439372
Nature. 2012 Sep 13;489(7415):242-9
pubmed: 22972297
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9388-93
pubmed: 12886019
J Cell Sci. 2009 Dec 15;122(Pt 24):4505-15
pubmed: 19934223
Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21270-5
pubmed: 19940242
Nature. 2006 Jan 26;439(7075):470-4
pubmed: 16340960
J Exp Biol. 2009 Jun;212(Pt 11):1731-44
pubmed: 19448082
Cell Metab. 2021 Dec 7;33(12):2428-2444.e8
pubmed: 34710355
Cell Host Microbe. 2014 Nov 12;16(5):592-604
pubmed: 25525791
Nat Rev Immunol. 2014 Dec;14(12):796-810
pubmed: 25421701
Nat Chem Biol. 2014 Jun;10(6):416-24
pubmed: 24838170
Annu Rev Genet. 2013;47:377-404
pubmed: 24016187
Nature. 2006 Jan 26;439(7075):475-9
pubmed: 16340959
Sci Rep. 2017 Nov 16;7(1):15713
pubmed: 29146985
Crit Care Med. 2000 Sep;28(9):3198-202
pubmed: 11008982
Immunol Lett. 2016 Feb;170:42-51
pubmed: 26730849
Curr Opin Biotechnol. 2013 Apr;24(2):160-8
pubmed: 22940212
Cell. 2001 Feb 23;104(4):487-501
pubmed: 11239407
Sci STKE. 2005 Oct 18;2005(306):re12
pubmed: 16234508
Front Endocrinol (Lausanne). 2017 Dec 13;8:349
pubmed: 29326657
Cell. 2005 Apr 8;121(1):115-25
pubmed: 15820683
Nature. 2002 Nov 21;420(6913):333-6
pubmed: 12447443
Cell Rep. 2018 Mar 6;22(10):2550-2556
pubmed: 29514084
Cell Rep. 2020 Jun 9;31(10):107736
pubmed: 32521261
Mol Biol Evol. 2005 Jun;22(6):1365-74
pubmed: 15758206
Cell Rep. 2014 Oct 9;9(1):40-47
pubmed: 25263556
mBio. 2018 Mar 6;9(2):
pubmed: 29511074
Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11414-9
pubmed: 16061818
Cell Host Microbe. 2019 Aug 14;26(2):240-251.e8
pubmed: 31350199
Insect Biochem Mol Biol. 2012 Oct;42(10):729-38
pubmed: 22796331
Trends Endocrinol Metab. 2017 Feb;28(2):131-142
pubmed: 27923532
Int J Mol Sci. 2020 Jun 29;21(13):
pubmed: 32610524
Environ Pollut. 2020 Mar;258:113671
pubmed: 31855676
Dev Comp Immunol. 2021 Mar;116:103904
pubmed: 33245980
J Insect Physiol. 2013 Feb;59(2):232-9
pubmed: 22771302
Nature. 2000 Sep 7;407(6800):81-6
pubmed: 10993077
Insects. 2020 Mar 07;11(3):
pubmed: 32156093
Vet Immunol Immunopathol. 2005 Jul 15;106(3-4):303-8
pubmed: 15876457
Proc Biol Sci. 2009 Nov 7;276(1674):3799-807
pubmed: 19692410
Science. 2006 Oct 13;314(5797):267
pubmed: 17038615
Immunity. 2004 May;20(5):637-49
pubmed: 15142531
Insect Mol Biol. 2003 Feb;12(1):93-7
pubmed: 12542640
Insect Biochem Mol Biol. 2015 Dec;67:15-20
pubmed: 25982023
Cell. 2013 May 9;153(4):797-811
pubmed: 23663779
PLoS Pathog. 2007 Mar;3(3):e41
pubmed: 17381241
PLoS Genet. 2020 Nov 23;16(11):e1009192
pubmed: 33227003
Cell Tissue Res. 2013 May;352(2):313-26
pubmed: 23397424
Dev Comp Immunol. 2019 Jan;90:21-28
pubmed: 30165084
Cell Metab. 2011 May 4;13(5):517-26
pubmed: 21531334
Front Physiol. 2021 Feb 24;11:630037
pubmed: 33716757
Immunity. 2011 Dec 23;35(6):871-82
pubmed: 22195744
Biochem J. 2003 Mar 15;370(Pt 3):1011-7
pubmed: 12479793
PLoS One. 2010 Aug 13;5(8):e12149
pubmed: 20730104
Science. 2012 May 4;336(6081):582-5
pubmed: 22556251
Acta Diabetol. 2013 Apr;50(2):189-200
pubmed: 21293887
ISME J. 2013 Oct;7(10):1922-32
pubmed: 23719154
Insects. 2012 Aug 15;3(3):789-820
pubmed: 26466629
Diabetes Res Clin Pract. 2014 Aug;105(2):141-50
pubmed: 24798950
Biochimie. 2017 Feb;133:56-65
pubmed: 28003126
Immun Ageing. 2016 May 01;13:15
pubmed: 27134635
Cell. 2016 Jan 28;164(3):406-19
pubmed: 26824654
J Insect Physiol. 2019 Aug - Sep;117:103894
pubmed: 31175854
Curr Biol. 2001 Feb 20;11(4):213-21
pubmed: 11250149
G3 (Bethesda). 2017 Aug 7;7(8):2427-2438
pubmed: 28620086
Adv Exp Med Biol. 2017;960:277-304
pubmed: 28585204