Elective Laparoscopic Paraesophageal Hernia Repair leads to an Increase in Life-Expectancy over Watchful Waiting in Asymptomatic Patients: An Updated Markov Analysis.
Journal
Annals of surgery
ISSN: 1528-1140
Titre abrégé: Ann Surg
Pays: United States
ID NLM: 0372354
Informations de publication
Date de publication:
11 Oct 2023
11 Oct 2023
Historique:
medline:
11
10
2023
pubmed:
11
10
2023
entrez:
11
10
2023
Statut:
aheadofprint
Résumé
The aim of this study was to perform an updated Markov analysis to determine the optimal management strategy for patients with an asymptomatic paraesophageal hernia (PEH): elective laparoscopic hernia repair (ELHR) versus watchful waiting (WW). Currently it is recommended that patients with an asymptomatic PEH not undergo repair based on a 20-year-old Markov analysis. The current recommendation might lead to preventable hospitalizations for acute PEH-related complications and compromised survival. A Markov model with updated variables was used to compare life-years (LYs) gained with ELHR versus WW in patients with a PEH. One-way sensitivity analyses evaluated the robustness of the analysis to alternative data inputs, while probabilistic sensitivity analysis quantified the level of confidence in the results in relation to the uncertainty across all model inputs. At age 40-90 ELHR led to greater life expectancy than WW, particularly in women. The gain in L-Ys (2.6) was greatest in a 40-year-old woman and diminished with increasing age. Sensitivity analysis showed that alternative values resulted in modest changes in the difference in L-Ys, but ELHR remained the preferred strategy. Probabilistic analysis showed that ELHR was the preferred strategy in 100% of 10,000 simulations for age 65, 98% for age 80, 90% for age 85 and 59% of simulations in 90-year-old women. This updated analysis showed that ELHR leads to an increase in L-Ys over WW in healthy patients aged 40-90 years with an asymptomatic PEH. In this new paradigm all patients with a PEH, regardless of symptoms, should be referred for consideration of elective repair to maximize their life expectancy.
Sections du résumé
OBJECTIVE
OBJECTIVE
The aim of this study was to perform an updated Markov analysis to determine the optimal management strategy for patients with an asymptomatic paraesophageal hernia (PEH): elective laparoscopic hernia repair (ELHR) versus watchful waiting (WW).
SUMMARY BACKGROUND DATA
BACKGROUND
Currently it is recommended that patients with an asymptomatic PEH not undergo repair based on a 20-year-old Markov analysis. The current recommendation might lead to preventable hospitalizations for acute PEH-related complications and compromised survival.
METHODS
METHODS
A Markov model with updated variables was used to compare life-years (LYs) gained with ELHR versus WW in patients with a PEH. One-way sensitivity analyses evaluated the robustness of the analysis to alternative data inputs, while probabilistic sensitivity analysis quantified the level of confidence in the results in relation to the uncertainty across all model inputs.
RESULTS
RESULTS
At age 40-90 ELHR led to greater life expectancy than WW, particularly in women. The gain in L-Ys (2.6) was greatest in a 40-year-old woman and diminished with increasing age. Sensitivity analysis showed that alternative values resulted in modest changes in the difference in L-Ys, but ELHR remained the preferred strategy. Probabilistic analysis showed that ELHR was the preferred strategy in 100% of 10,000 simulations for age 65, 98% for age 80, 90% for age 85 and 59% of simulations in 90-year-old women.
CONCLUSIONS
CONCLUSIONS
This updated analysis showed that ELHR leads to an increase in L-Ys over WW in healthy patients aged 40-90 years with an asymptomatic PEH. In this new paradigm all patients with a PEH, regardless of symptoms, should be referred for consideration of elective repair to maximize their life expectancy.
Identifiants
pubmed: 37818675
doi: 10.1097/SLA.0000000000006119
pii: 00000658-990000000-00666
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest.