Role of the rostral dorsomedial column of the periaqueductal gray during social defeat in rats.
defensive behavior
hypothalamus
mesencephalon
social fear
social stress
Journal
Annals of the New York Academy of Sciences
ISSN: 1749-6632
Titre abrégé: Ann N Y Acad Sci
Pays: United States
ID NLM: 7506858
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
pubmed:
11
10
2023
medline:
11
10
2023
entrez:
11
10
2023
Statut:
ppublish
Résumé
Previous studies showed that the dorsal premammillary nucleus of the hypothalamus (PMD) is involved in social passive defensive behaviors likely to be meditated by descending projections to the periaqueductal gray (PAG). We focused on the rostral dorsomedial PAG (rPAGdm) to reveal its putative neural mechanisms involved in mediating social defensive responses. By combining retrograde tracing and FOS expression analysis, we showed that in addition to the PMD, the rPAGdm is influenced by several brain sites active during social defeat. Next, we found that cytotoxic lesions of the rPAGdm drastically reduced passive defense and did not affect active defensive responses. We then examined the rPAGdm's projection pattern and found that the PAGdm projections are mostly restricted to midbrain sites, including the precommissural nucleus, different columns of the PAG, and the cuneiform nucleus (CUN). Also, we found decreased FOS expression in the caudal PAGdm, CUN, and PMD after the rPAGdm was lesioned. The results support that the rPAGdm mediates passive social defensive responses through ascending paths to prosencephalic circuits likely mediated by the CUN. This study provides further support for the role of the PAG in the modulation of behavioral responses by working as a unique hub for influencing prosencephalic sites during the mediation of aversive responses.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
138-151Subventions
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 150992/2022-0
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2016/18667-0
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2021/02864-9
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2022/07530-4
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2021/05413-8
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2010/05905-3
Informations de copyright
© 2023 The New York Academy of Sciences.
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