Nanopore Signatures of Nucleoside Drugs.

Mycobacterium smegmatis porin A nanopore nucleoside drugs phenylboronic acid single-molecule sensing

Journal

Nano letters
ISSN: 1530-6992
Titre abrégé: Nano Lett
Pays: United States
ID NLM: 101088070

Informations de publication

Date de publication:
25 10 2023
Historique:
medline: 26 10 2023
pubmed: 11 10 2023
entrez: 11 10 2023
Statut: ppublish

Résumé

Nucleoside drugs, which are analogues of natural nucleosides, have been widely applied in the clinical treatment of viral infections and cancers. The development of nucleoside drugs, repurposing of existing drugs, and combined use of multiple drug types have made the rapid sensing of nucleoside drugs urgently needed. Nanopores are emerging single-molecule sensors that have high resolution to resolve even minor structural differences between chemical compounds. Here, an engineered

Identifiants

pubmed: 37818841
doi: 10.1021/acs.nanolett.3c02872
doi:

Substances chimiques

Nucleosides 0
Porins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9437-9444

Auteurs

Wendong Jia (W)

State Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China.
Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, 210023 Nanjing, China.

Yusheng Ouyang (Y)

State Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China.
Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, 210023 Nanjing, China.

Shanyu Zhang (S)

State Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China.
Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, 210023 Nanjing, China.

Xiaoyu Du (X)

State Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China.
Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, 210023 Nanjing, China.

Panke Zhang (P)

State Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China.

Shuo Huang (S)

State Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, China.
Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, 210023 Nanjing, China.

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