Effect of Cardiac Arrest in Brain-dead Donors on Kidney Graft Function.
Journal
Transplantation
ISSN: 1534-6080
Titre abrégé: Transplantation
Pays: United States
ID NLM: 0132144
Informations de publication
Date de publication:
11 Oct 2023
11 Oct 2023
Historique:
medline:
11
10
2023
pubmed:
11
10
2023
entrez:
11
10
2023
Statut:
aheadofprint
Résumé
Cardiac arrest (CA) causes renal ischemia in one-third of brain-dead kidney donors before procurement. We hypothesized that the graft function depends on the time interval between CA and organ procurement. We conducted a retrospective population-based study on a prospectively curated database. We included 1469 kidney transplantations from donors with a history of resuscitated CA in 2015-2017 in France. CA was the cause of death (primary CA) or an intercurrent event (secondary CA). The main outcome was the percentage of delayed graft function, defined by the use of renal replacement therapy within the first week posttransplantation. Delayed graft function occurred in 31.7% of kidney transplantations and was associated with donor function, vasopressors, cardiovascular history, donor and recipient age, body mass index, cold ischemia time, and time to procurement after primary cardiac arrest. Short cold ischemia time, perfusion device use, and the absence of cardiovascular comorbidities were protected by multivariate analysis, whereas time <3 d from primary CA to procurement was associated with delayed graft function (odds ratio 1.38). This is the first description of time to procurement after a primary CA as a risk factor for delayed graft function. Delaying procurement after CA should be evaluated in interventional studies.
Sections du résumé
BACKGROUND
BACKGROUND
Cardiac arrest (CA) causes renal ischemia in one-third of brain-dead kidney donors before procurement. We hypothesized that the graft function depends on the time interval between CA and organ procurement.
METHODS
METHODS
We conducted a retrospective population-based study on a prospectively curated database. We included 1469 kidney transplantations from donors with a history of resuscitated CA in 2015-2017 in France. CA was the cause of death (primary CA) or an intercurrent event (secondary CA). The main outcome was the percentage of delayed graft function, defined by the use of renal replacement therapy within the first week posttransplantation.
RESULTS
RESULTS
Delayed graft function occurred in 31.7% of kidney transplantations and was associated with donor function, vasopressors, cardiovascular history, donor and recipient age, body mass index, cold ischemia time, and time to procurement after primary cardiac arrest. Short cold ischemia time, perfusion device use, and the absence of cardiovascular comorbidities were protected by multivariate analysis, whereas time <3 d from primary CA to procurement was associated with delayed graft function (odds ratio 1.38).
CONCLUSIONS
CONCLUSIONS
This is the first description of time to procurement after a primary CA as a risk factor for delayed graft function. Delaying procurement after CA should be evaluated in interventional studies.
Identifiants
pubmed: 37819189
doi: 10.1097/TP.0000000000004825
pii: 00007890-990000000-00567
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Inserm
ID : 2019 ATIP Avenir grant
Investigateurs
Martial Ouendo
(M)
Alice Aarninck
(A)
Aurore Armand
(A)
Lionel Badet
(L)
Dominique Bertrand
(D)
Thomas Bessede
(T)
Romain Boisser
(R)
Nicolas Bouvier
(N)
Franck Bruyere
(F)
Mathias Buchler
(M)
Fanny Buron
(F)
Florian Ceruti
(F)
Nabil Chakfe
(N)
Bertrand Chauveau
(B)
Romain Chauvet
(R)
Gaëlle Cheisson
(G)
Gabriel Choukroun
(G)
Mathieu Cornuault
(M)
Arnaud Del Bello
(A)
Didier Ducloux
(D)
Magali Epinat
(M)
Pascal Eschwege
(P)
Anne-Laure Fedou
(AL)
François Gaudez
(F)
Sophie Girerd
(S)
Léonard Golbin
(L)
None Grall-Jezequel
Arnaud Gregoire
(A)
Hélène Gregoire
(H)
Philippe Grimbert
(P)
Guillaume Ducos
(G)
Yves-Marie Guillou
(YM)
Marc Hazzan
(M)
Arwa Jalal-Eddine
(A)
Frédéric Jambon
(F)
Bénédicte Janbon
(B)
Nassim Kamar
(N)
Hannah Kaminski
(H)
Thomas Kerforne
(T)
Luca Lanfranco
(L)
Yannick LE Meur
(Y)
Eric Lechevallier
(E)
Carmen Lefaucheur
(C)
Tristan Legris
(T)
Anne Lejay
(A)
Rémi Lenain
(R)
Marc Leone
(M)
Nicolas Maillard
(N)
Medhi Manaoui
(M)
Xavier Matillon
(X)
Alexandre Mebaaza
(A)
Clémentine Millet
(C)
Valérie Moal
(V)
Florent Montini
(F)
Emmanuel Morelon
(E)
Johan Noble
(J)
Arthur Orieux
(A)
Marc Padilla
(M)
Bastien Parier
(B)
Jean Picquet
(J)
Benoit Plaud
(B)
Sébastien Prin
(S)
Thomas Prudhomme
(T)
Rose-Marie Rebillard
(RM)
Julien Rogier
(J)
Federico Sallusto
(F)
Charlotte Salmon-Gandonniere
(C)
Anne Gaelle Si Larbi
(AG)
Renaud Snanoudj
(R)
Yanish Soorojebally
(Y)
Nicolas Terrier
(N)
Antoine Thierry
(A)
Rodolphe Thuret
(R)
Maxime Vallee
(M)
Nicolas Vedrine
(N)
Jean Christophe Venhard
(JC)
Philippe Coordination Wolf
(PC)
Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Références
Wolfe RA, McCullough KP, Leichtman AB. Predictability of survival models for waiting list and transplant patients: calculating LYFT. Am J Transplant. 2009;9:1523–1527.
Wolfe RA, Ashby VB, Milford EL, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med. 1999;341:1725–1730.
Wyld M, Morton RL, Hayen A, et al. A systematic review and meta-analysis of utility-based quality of life in chronic kidney disease treatments. PLoS Med. 2012;9:e1001307.
Axelrod DA, Schnitzler MA, Xiao H, et al. An economic assessment of contemporary kidney transplant practice. Am J Transplant. 2018;18:1168–1176.
McCormick F, Held PJ, Chertow GM. The terrible toll of the kidney shortage. J Am Soc Nephrol. 2018;29:2775–2776.
Heilman RL, Smith ML, Smith BH, et al. Long-term outcomes following kidney transplantation from donors with acute kidney injury. Transplantation. 2019;103:e263–e272.
Elmer J, Molyneaux BJ, Shutterly K, et al. Organ donation after resuscitation from cardiac arrest. Resuscitation. 2019;145:63–69.
Hinzmann J, Grzella S, Lengenfeld T, et al. Impact of donor cardiopulmonary resuscitation on the outcome of simultaneous pancreas-kidney transplantation-a retrospective study. Transpl Int. 2020;33:644–656.
Dutta A, Hari KJ, Azizian J, et al. Incidence, predictors, and prognosis of acute kidney injury among cardiac arrest survivors. J Intensive Care Med. 2020;36:550–556.
Hasz R, West SM, Nathan HM. An 81% increase in organ donors from anoxic deaths in one OPO. Transplantation. 2017;101:S10.
Messner F, Yu Y, Etra JW, et al. Donor cardiac arrest and cardiopulmonary resuscitation: impact on outcomes after simultaneous pancreas-kidney transplantation - a retrospective study. Transpl Int. 2020;33:657–666.
Kostakis ID, Kassimatis T, Flach C, et al. Hypoperfusion warm ischaemia time in renal transplants from donors after circulatory death. Nephrol Dial Transplant. 2020;35:1628–1634.
Heylen L, Naesens M, Jochmans I, et al. The effect of anastomosis time on outcome in recipients of kidneys donated after brain death: a cohort study. Am J Transplant. 2015;15:2900–2907.
Blasco V, Leone M, Bouvenot J, et al. Impact of intensive care on renal function before graft harvest: results of a monocentric study. Crit Care. 2007;11:R103.
Costa SD, de Andrade LGM, Barroso FVC, et al. The impact of deceased donor maintenance on delayed kidney allograft function: a machine learning analysis. PLoS One. 2020;15:e0228597.
Jonas M, Warzyszyńska K, Olszewska N, et al. Influence of sudden cardiac arrest in deceased kidney donors on organ function after transplantation. Transplant Proc. 2018;50:1979–1981.
Park SE, Yoon SS, Park SC, et al. Analysis of pre-transplant resuscitation factors influencing immediate graft function after deceased donor kidney transplantation. Transplant Proc. 2018;50:3088–3094.
West S, Soar J, Callaway CW. The viability of transplanting organs from donors who underwent cardiopulmonary resuscitation: a systematic review. Resuscitation. 2016;108:27–33.
Koyawala N, Parikh CR. A review of donor acute kidney injury and posttransplant outcomes. Transplantation. 2020;104:1553–1559.
Humphreys BD, Valerius MT, Kobayashi A, et al. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell. 2008;2:284–291.
Galichon P, Lannoy M, Li L, et al. Kidney epithelial proliferation impairs cell viability via energy depletion. bioRxiv. 2021;2020.04.24.054643.
Khwaja A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract. 2012;120:c179–c184.
Patel MS, De La Cruz S, Sally MB, et al. Active donor management during the hospital phase of care is associated with more organs transplanted per donor. J Am Coll Surg. 2017;225:525–531.
Textor J, van der Zander B, Gilthorpe MS, et al. Robust causal inference using directed acyclic graphs: the R package “dagitty.” Int J Epidemiol. 2016;45:1887–1894.
Hariharan S, Israni AK, Danovitch G. Long-term survival after kidney transplantation. N Engl J Med. 2021;385:729–743.
Siedlecki A, Irish W, Brennan DC. Delayed graft function in the kidney transplant. Am J Transplant. 2011;11:2279–2296.
Yarlagadda SG, Coca SG, Formica RN, et al. Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis. Nephrol Dial Transplant. 2009;24:1039–1047.
Kunzendorf U, Hohenstein B, Oberbarnscheid M, et al. Duration of donor brain death and its influence on kidney graft function. Am J Transplant. 2002;2:292–294.
Eerola V, Helanterä I, But A, et al. The association of time to organ procurement on short- and long-term outcomes in kidney transplantation. Clin J Am Soc Nephrol. 2021;16:427–436.
Niemann CU, Feiner J, Swain S, et al. Therapeutic hypothermia in deceased organ donors and kidney-graft function. N Engl J Med. 2015;373:405–414.
Sandroni C, Dell’anna AM, Tujjar O, et al. Acute kidney injury after cardiac arrest: a systematic review and meta-analysis of clinical studies. Minerva Anestesiol. 2016;82:989–999.