1-Azaspiro[3.3]heptane as a Bioisostere of Piperidine.
1-Azaspiro[3.3]Heptane
Bioisosteres
Drug Design
Medicinal Chemistry
Piperidine
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
18 Dec 2023
18 Dec 2023
Historique:
received:
15
08
2023
medline:
11
10
2023
pubmed:
11
10
2023
entrez:
11
10
2023
Statut:
ppublish
Résumé
1-Azaspiro[3.3]heptanes were synthesized, characterized, and validated biologically as bioisosteres of piperidine. The key synthesis step was thermal [2+2] cycloaddition between endocyclic alkenes and the Graf isocyanate, ClO
Identifiants
pubmed: 37819253
doi: 10.1002/anie.202311583
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202311583Subventions
Organisme : HORIZON EUROPE European Research Council
ID : 101000893
Informations de copyright
© 2023 The Authors. Published by Wiley-VCH GmbH.
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Deposition numbers 2253048 (1 a ⋅ HCl), 2253050 (Boc-14 a), 2253518 (15), 2253051 (Boc2-16 a), 2253517 (28 a ⋅ HCl), 2253052 (30 ⋅ 2HCl), 2253053 (32), 2253054 (34 ⋅ HCl), 2253055 (37), 2253056 (47 ⋅ HCl), 2253057 (50), 2253049 (51 ⋅ HCl), 2299371 (63), 2299370 (64) contain the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe Access Structures service.
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